Rchr
J-GLOBAL ID:201801019969750806   Update date: Jul. 31, 2024

Yasuyuki Gen

Yasuyuki Gen
Affiliation and department:
Research field  (1): Tumor diagnostics and therapeutics
Research theme for competitive and other funds  (5):
  • 2019 - 2022 新規癌抑制型miRNAによるMYC標的核酸抗癌薬の開発
  • 2018 - 2021 Development of therapeutic miRNAs targeting BET family protein BRD4 for cancer
  • 2015 - 2020 Establishment of novel concept for cancer diagnostics and therapeutics based on the systematic comprehension of cellular context in cancer
  • 2015 - 2018 食道扁平上皮癌の増幅遺伝子SOX2のmiRNA発現制御を介した発癌促進機構の解明
  • 2012 - 2015 食道癌の増幅遺伝子SOX2のAKT経路を介した腫瘍増殖機序の解明と治療への応用
Papers (41):
  • Tomohiro Soda, Yasuyuki Gen, Kei Terasaki, Naoto Iwai, Tomoko Kitaichi, Osamu Dohi, Hiroyoshi Taketani, Yuya Seko, Atsushi Umemura, Taichiro Nishikawa, et al. Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach. Scientific reports. 2022. 12. 1. 5050-5050
  • Chang Liu, Yasuyuki Gen, Kousuke Tanimoto, Tomoki Muramatsu, Jun Inoue, Johji Inazawa. Concurrent targeting of MAP3K3 and BRD4 by miR-3140-3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells. Molecular Therapy - Nucleic Acids. 2021. 25. 83-92
  • Yasuyuki Gen, Tomoki Muramatsu, Jun Inoue, Johji Inazawa. miR-766-5p targets super-enhancers by downregulating CBP and BRD4. Cancer research. 2021. 81. 20. 5190-5201
  • Terasaki K, Gen Y, Iwai N, Soda T, Kitaichi T, Dohi O, Taketani H, Seko Y, Umemura A, Nishikawa T, et al. SOX2 enhances cell survival and induces resistance to apoptosis under serum starvation conditions through the AKT/GSK-3β signaling pathway in esophageal squamous cell carcinoma. Oncol Lett. 2021. 21. 4. 269-269
  • Kenta Takahashi, Yasuyuki Gen, Kousuke Tanimoto, Atsushi Kudo, Noriko Oshima, Daisuke Ban, Akira Takemoto, Iichiro Onishi, Yuichi Kumaki, Junko Yokobori, et al. Clinical impact of hemizygous deletion detection and panel-size in comprehensive genomic profiling. Journal of Clinical Oncology. 2020. 38. 15_suppl. e15671-e15671
more...
MISC (47):
Education (2):
  • 2006 - 2010 Kyoto Prefectural University of Medicine
  • 1996 - 2002 Kyoto Prefectural University of Medicine
Professional career (1):
  • 医学博士 (京都府立医科大学大学院)
Work history (2):
  • 2016/11 - 現在 -
  • 2010/04 - 2016/10 Kyoto Prefectural University of Medicine
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