Research field (2)：
Developmental biology
, Laboratory animal science
Research keywords (2)：
Biology of Reproduction
, Laboratory Animal Science
Research theme for competitive and other funds (5)：
2023 - 2026 精子形成過程に出現する球状ミトコンドリアの形成メカニズムに迫る
2020 - 2023 Analysis of mitochondrial sheath formation mechanism using KO mice
2017 - 2020 Revealing the mechanism of mitochondrial localization in the sperm midpiece
精子形成期後半に発生する 2 つの異なる nuage の機能と役割の解明
Elucidation of molecular mechanisms involved in sperm mitochondrial dynamics
Papers (30)：
Zian Liao, Suni Tang, Kaori Nozawa, Keisuke Shimada, Masahito Ikawa, Diana Monsivais, Martin Matzuk. Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy. eLife. 2024
Tsutomu Endo, Kiyonori Kobayashi, Takafumi Matsumura, Chihiro Emori, Manabu Ozawa, Shimpei Kawamoto, Daisuke Okuzaki, Keisuke Shimada, Haruhiko Miyata, Kentaro Shimada, et al. Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice. Communications Biology. 2024
Keisuke Shimada, Masahito Ikawa. CCDC183 is essential for cytoplasmic invagination around the flagellum during spermiogenesis and male fertility. Development. 2023
Keisuke Shimada, Yonggang Lu, Masahito Ikawa. Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility. Experimental animals. 2023
Keisuke Shimada, Soojin Park, Seiya Oura, Taichi Noda, Akane Morohoshi, Martin M Matzuk, Masahito Ikawa. TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 11. e2221762120
大山裕貴, 大山裕貴, 宮田治彦, 嶋田圭祐, 藤原祥高, 徳弘圭造, THOMAS Garcia, MARTIN Matzuk, 伊川正人, 伊川正人, et al. 精巣で発現する12遺伝子はマウス雄性生殖能力に必須ではない. 日本アンドロロジー学会総会記事. 2021. 40th
Lectures and oral presentations (20)：
Molecular mechanism analysis involved in mitochondrial sheath formation and spermiation processes using gene-manipulated mice
(IMP seminar at research Institute of Molecular Pathology 2023)
TSKS-derived nuages regulate the transportation of cytoplasmic contents during spermiation
(European testis workshop 2023 2023)
2019/01 - Research Institute for Microbial Diseases, Osaka University Biken Best Academic Award
Association Membership(s) (6)：
日本実験動物学会
, Japan Society of Andrology
, Society for the Study of Reproduction
, 日本実験動物医学専門医協会
, Japanese Association for Laboratory Animal Medicine
, THE JAPANESE SOCIETY OF VETERINARY SCIENCE
