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J-GLOBAL ID：201801020209113529   Update date: Sep. 17, 2024

Urushima Hayato

ウルシマ ハヤト | Urushima Hayato
Affiliation and department：
Osaka Metropolitan University Graduate School of Medicine Basic Medicine Course

About Osaka Metropolitan University Graduate School of Medicine Basic Medicine Course


Research field  (1)： Gastroenterology
Research theme for competitive and other funds  (7)：
  • 2024 - 2027 Unmet Medical Needsである低アルブミン血症に対する改善候補化合物の分子機序解明
  • 2021 - 2024 肝星細胞の初期活性化のメカニズム解明と生体外での類洞再構築ならびに人工肝への応用
  • 2020 - 2023 Pile-up型増殖に着目した新規肝細胞培養法確立および肝がん治療化合物の探索
  • 2019 - 2020 肝線維化を伴う難治疾患と肝星細胞におけるプリオン発現の関連
  • 2018 - 2020 Elucidation of activation mechanism of hepatic stellate cells through mechano-transduction
Show all
Papers (23)：
  • Hanh Vinh Ngo, Thuy Thi Thanh Le, Hieu Ngoc Vu, Hai Hoang, Hiroko Ikenaga, Misako Sato-Matsubara, Sawako Uchida-Kobayashi, Hayato Urushima, Khanh Van Nguyen, Ha Thi Nguyen, et al. Poorly Differentiated Hepatocellular Carcinoma Cells Avoid Apoptosis by Interacting with T Cells via CD40-CD40L Linkage. The American journal of pathology. 2024
  • Takehisa Nakanishi, Shohei Iida, Junko Maruyama, Hayato Urushima, Masako Ichishi, Yoshiaki Matsushima, Kento Mizutani, Yuichi Nakayama, Kyoko Sugioka, Mai Nishimura, et al. Arteriosclerosis Derived from Cutaneous Inflammation Is Ameliorated by the Deletion of IL-17A and IL-17F. International journal of molecular sciences. 2023. 24. 6
  • Hayato Urushima, Tsutomu Matsubara, Masaaki Miyakoshi, Shioko Kimura, Hideto Yuasa, Katsutoshi Yoshizato, Kazuo Ikeda. Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway. American journal of physiology. Gastrointestinal and liver physiology. 2023. 324. 3. G219-G230
  • Minh Phuong Dong, Le Thi Thanh Thuy, Dinh Viet Hoang, Hoang Hai, Truong Huu Hoang, Misako Sato-Matsubara, Vu Ngoc Hieu, Atsuko Daikoku, Ngo Vinh Hanh, Hayato Urushima, et al. Soluble Immune Checkpoint Protein CD27 Is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C Virus-Sustained Virological Response Patients. The American journal of pathology. 2022. 192. 10. 1379-1396
  • Truong Huu Hoang, Misako Sato-Matsubara, Hideto Yuasa, Tsutomu Matsubara, Le Thi Thanh Thuy, Hiroko Ikenaga, Dong Minh Phuong, Ngo Vinh Hanh, Vu Ngoc Hieu, Dinh Viet Hoang, et al. Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms. Science advances. 2022. 8. 39. eabo5525
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MISC (6)：
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Lectures and oral presentations  (32)：
  • 肝星細胞-肝細胞間の接着と肝星細胞活性化との関係について
    (第14回中四国電子顕微鏡研究会 2019)
  • 正常肝ないし障害肝の肝星細胞におけるfilopodia関連タンパク質の発現解析
    (第33回肝類洞壁細胞研究会 2019)
  • Stellate cells initiate the activation by the loss of adherens junction with hepatocytes
    (20th International Symposium on Cells of Hepatic Sinusoid 2019)
  • 門亢症の病態解明〜基礎から臨床へ〜 肝硬変時の低ナトリウム血症による低浸透圧環境が門脈圧亢進に及ぼす影響
    (日本門脈圧亢進症学会雑誌 2019)
  • Liver regeneration from acute liver injury is promoted by Oligonol®, a low-molecular-weight polyphenol derived from lychee fruit
    (27 th International Congress on Nutrition and Integrative Medicine 2019)
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Education (2)：
  • Tottori University Faculty of Agriculture
  • Osaka University Graduate School, Division of Medical Sciences
Professional career (1)：
  • 博士(医学) (大阪大学)
Work history (4)：
  • 2024/04 - 現在 大阪公立大学医学部動物実験施設
  • 2021/07 - 現在 大阪市立大学大学院医学研究科 機能細胞形態学 講師
  • 2016/10 - 2021/06 Osaka City University Graduate School of Medicine Basic Medicine Course Assistant Professor
  • 2015/04/01 - 2016/09/30 国立研究開発法人医薬基盤健康栄養研究所 特任研究員
Awards (5)：
  • 2023/12 - 肝類洞壁細胞研究会 優秀演題賞 増殖様式が異なるHepG2細胞2系統間の遺伝子比較と肝機能改善剤スクリーニングシステムの構築
  • 2018/07/21 - 統合医療機能性食品国際学会 優秀ポスター報告賞
  • 2018/04/08 - Kansai Liver Club 2018 優秀賞
  • 2018/03/17 - 大阪市立大学医学部 Teacher of the Year
  • 2013 - International Congress on Nutrition and Integrative Medicine 若手研究奨励賞
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