Rchr
J-GLOBAL ID：201801020236689432   Update date: Oct. 31, 2024

Shuhei Sakakibara

サカキバラ シュウヘイ | Shuhei Sakakibara
Affiliation and department：
Jikei University of Health Care Sciences Graduate School of Medical Safety Management

About Jikei University of Health Care Sciences Graduate School of Medical Safety Management


Job title： Associate Professor
Other affiliations (1)：
  • Osaka University  WPI Immunology Frontier Research Center   Visiting Associate Professor
Research field  (2)： Virology ,  Immunology
Research keywords  (4)： Virology ,  Allergy ,  Autoimmune Diseases ,  Immunology
Research theme for competitive and other funds  (9)：
  • 2020 - 2023 Development, validation and application of machine learning system for TCR epitope prediction
  • 2019 - 2022 全身性エリテマトーデスにおける抗DNA B細胞の親和性増大とその制御
  • 2020 - 2021 公益財団法人 持田記念医学薬学振興財団 研究助成金 「好酸球副鼻腔炎における病原性T 細胞の同定と性状解析」
  • 2019 - 2021 公益財団法人 武田医学振興財団 医学系研究助成 「全身性エリテマトーデスにおけるdsDNA反応性B細胞の親和性成熟機構の解明」
  • 2016 - 2019 体細胞超変異による自己反応性B細胞出現モデルの構築と末梢性B細胞自己寛容の解明
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Papers (50)：
  • Shuhei Sakakibara, Yu-Chen Liu, Masakazu Ishikawa, Ryuya Edahiro, Yuya Shirai, Soichiro Haruna, Marwa Ali El Hussien, Zichang Xu, Songling Li, Yuta Yamaguchi, et al. Clonal landscape of autoantibody-secreting plasmablasts in COVID-19 patients. Life Science Alliance. 2024. 7. 12. e202402774-e202402774
  • Maha M. Elbrashy, Hozaifa Metwally, Shuhei Sakakibara, Tadamitsu Kishimoto. Threonine Phosphorylation and the Yin and Yang of STAT1: Phosphorylation-Dependent Spectrum of STAT1 Functionality in Inflammatory Contexts. Cells. 2024. 13. 18. 1531-1531
  • Yu-Chen Liu, Masakazu Ishikawa, Shuhei Sakakibara, Mohamad Al Kadi, Daisuke Motooka, Yoko Naito, Shingo Ito, Yuko Imamura, Hisatake Matsumoto, Fuminori Sugihara, et al. Full-length nanopore sequencing of circular RNA landscape in peripheral blood cells following sequential BNT162b2 mRNA vaccination. Gene. 2024. 148971-148971
  • David G. Priest, Takeshi Ebihara, Janyerkye Tulyeu, Jonas N. Søndergaard, Shuhei Sakakibara, Fuminori Sugihara, Shunichiro Nakao, Yuki Togami, Jumpei Yoshimura, Hiroshi Ito, et al. Atypical and non-classical CD45RBlo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19. Nature Communications. 2024. 15. 1
  • Dianita S. Saputri, Hendra S. Ismanto, Dendi K. Nugraha, Zichang Xu, Yasuhiko Horiguchi, Shuhei Sakakibara, Daron M. Standley. Deciphering the antigen specificities of antibodies by clustering their complementarity determining region sequences. mSystems. 2023
ｍore...
MISC (4)：
  • 枝廣 龍哉, 白井 雄也, 竹島 雄介, 榊原 修平, 山口 勇太, 村上 輝明, 森田 貴義, 加藤 保宏, Liu Yu-Chen, 元岡 大祐, et al. シングルセル情報とゲノム情報の統合解析によるCOVID-19重症化メカニズムの解明. 日本呼吸器学会誌. 2024. 13. 増刊. 166-166
  • David G. Priest, Takeshi Ebihara, Janyerkye Tulyeu, Jonas Søndergaard, Shuhei Sakakibara, Fuminori Sugihara, Shunichiro Nakao, Yuki Togami, Jumpei Yoshimura, Hiroshi Ito, et al. Non-classical CD45RBlo memory B-cells are the majority of circulating antigen-specific B-cells following mRNA vaccination and COVID-19 infection. 2024
  • 枝廣龍哉, 枝廣龍哉, 白井雄也, 白井雄也, 白井雄也, 竹島雄介, 榊原修平, 山口勇太, 山口勇太, 村上輝明, et al. Elucidating the mechanism of COVID-19 severity by integrative analysis of single-cell and host genetics data. 日本呼吸器学会誌(Web). 2024. 13
  • 伊藤 弘, 石川 昌和, 吉村 旬平, 劉 祐誠, 松本 寿健, 杉原 文徳, 榊原 修平, 奥崎 大介, 平田 陽彦, 小倉 裕司, et al. RNA解析を用いたCOVID-19によるARDSの病態解明. 日本集中治療医学会雑誌. 2023. 30. Suppl.1. S586-S586
Patents (1)：
  • Glycosylated rbd and use thereof
Books (4)：
  • アレルギー性真菌性鼻副鼻腔炎における炎症局所IgE産生:クローンレベルの特徴から理解する病態生理
    2024
  • アレルギー性副鼻腔炎と防御性粘膜免疫のアレルギー転換
    2023
  • 難治性アレルギー疾患の病態解明と治療法の開発
    2021
  • Autoantibody production during viral infection
    科学評論社 2014
Lectures and oral presentations  (10)：
  • RNA解析を用いたCOVID-19によるARDSの病態解明
    (日本集中治療医学会雑誌 2023)
  • シングルセル情報とゲノム情報の統合解析によるCOVID-19重症化メカニズムの解明
    (Proceedings for Annual Meeting of The Japanese Pharmacological Society 2023)
  • Single cell RNA-seq of Neutrophils from Severe COVID-19 Patients
    (日本分子生物学会年会プログラム・要旨集(Web) 2022)
  • Production of IgE antibodies broadly cross-reactive to cell wall polysaccharides of multiple fungi in nasal mucosa of patients with allergic fungal rhinosinusitis
    (The 50th Annual Meeting of the Japanese Society of Immunlogy 2021)
  • Multiple tolerance checkpoints suppress generation and activation of B cells producing low-affinity germline precursors of SLE patient-derived high- affinity anti-dsDNA antibody in BCR knock-in mice
    (The 48th Annual Meeting of the Japanese Society for Immunology 2019)
ｍore...
Education (3)：
  • 2001 - 2005 Osaka University Graduate School of Medicine
  • 1999 - 2001 Osaka University Graduate School of Medicine
  • 1995 - 1999 Osaka City University Faculty of Engineering Department of Applied Chemistry and Bioengineering,
Professional career (1)：
  • 博士 (大阪大学)
Work history (9)：
  • 2023/04 - 現在 Jikei University of Health Care Sciences Graduate School of Medical Safety Management Associate Professor
  • 2022/04 - 2023/03 Osaka University WPI Immunology Frontier Research Center Specially-appointed Assistant Professor (Part-time)
  • 2019/04 - 2022/03 Osaka University Immunology Frontier Research Center Endowed Chair Associate Professor
  • 2016/04 - 2019/03 Osaka University Immunology Frontier Research Center Endowed Chair Assistant Professor
  • 2011/06 - 2016/03 Osaka University Research Institute for Microbial Diseases Assistant Professor
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Awards (3)：
  • 2015/11 - The Japanese Society for Immunology Best Presentation Award "Antigen-specific maturation of anti-nuclear antibodies in systemic lupus erythematosus"
  • 2009 - JSPS 海外特別研究員 (NIH)
  • 2003 - JSPS 特別研究員奨励費 (学振DC2) カポシ肉腫関連ヘルペスウイルス潜伏感染機構の解明とその制御
Association Membership(s) (5)：
The Japanese Society for Regenerative Medicine ,  Japanese Society for Safety Education Research in Healthcare ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY FOR IMMUNOLOGY ,  The Japanese Society of Virology
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