Yasaka Toshiharu

ヤサカトシハル | Yasaka Toshiharu

Affiliation and department：
Homepage URL (1)： https://www.nuhw.ac.jp/faculty/health/hn/teacher/yasaka.html

Research field (4)： Physiology , Nervous system function , Neuroscience - general , Neuroanatomy and physiology

Research keywords (36)： synaptic glomeruli , itch , touch , 大縫線核 , Locus ceruleus , parabrachial nucleus , 痛覚 , 免疫細胞化学 , GABAニューロン , 介在ニューロン , Calretinin , Parvalbumin , nNOS , Dynorphin , Galanin , Substance P , GRP , NPY , Somatostatin , 慢性疼痛 , Pain , Gate control , Neuropeptide , Presynaptic inhibition , Low-threshold mechanoreceptor , Nociceptor , Primary afferent , Immunohistochemistry , Chronic pain , Patch-clamp , 局所神経回路 , 神経免疫 , ミクログリア , 痛み , インターニューロン , 脊髄後角

Research theme for competitive and other funds (19)：

2024 - 2028 筋/筋膜の温受容をトリガーとする中枢性鎮痛機構の解明
2023 - 2026 Descending pain control system plasticity and the effects of exercise therapy in rodents with chronic inframatory back pain.
2021 - 2024 代謝伝達物質としての乳酸から見えてきた、活動筋-交感神経フィードバック神経回路
2021 - 2024 痛みと痒みのラベルドライン神経回路における脊髄後角モジュールの同定
2019 - 2024 Elucidation of abnormal functioning of neuronal circuits underlying neuropathic pain and its application for drug discovery

2020 - 2023 神経節マクロファージとニューロンとのコンタクトは神経因性疼痛のスイッチとなるか?

2018 - 2021 ミクログリアはニューロンに接触して何をしているのか?-疼痛モデルによる解析-

2016 - 2019 Establishment of the model mouse and elucidation of the onset mechanism for development of therapeutic basis in Sotos syndrome

2015 - 2019 Study for the mechanism underlying neuropathic pain focusing on a subpopulation of microglia

2017 - 2019 Elucidation of the pathology of maxillofacial analgesia targeting the nerve-immune system of trigeminal ganglion and development of therapeutic method

2016 - 2019 慢性痛動物モデルに対するインターロイキン-27投与の効果

2015 - 2018 Roles of receptors for damage-associated molecular patterns on neuropathic pain

2014 - 2017 Discovery of cytokine contributing to physiological sensory sensitivity adjustment and elucidation of controlling mechanism of pain

2014 - 2017 Optogenetic manipulation of spinal local circuit which modulate pain/itch transmission

2012 - 2015 Roles of a newly identified pattern-recognition receptor family which activate innate immunity in development of neuropathic pain.

2011 - 2013 Investigation of the spinal local circuit involved in pain signal transmission in the superficial dorsal horn.

2000 - 2002 Analysis of adaptation mechanisms during environmental stress through the neural-immune interaction.

1999 - 2000 環境ストレスによるサイトカイン脳内発現のホメオスタシス反応における意義

1998 - 2000 Roles of brain mast cells and their related substances in the central mechanisms of stress responses

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Papers (23)：

Yuki Kambe, Thanh Trung Nguyen, Toshiharu Yasaka, Thu Thi Nguyen, Yoshimune Sameshima, Kohei Hashiguchi, Norihito Shintani, Hitoshi Hashimoto, Takashi Kurihara, Atsuro Miyata. The Pivotal Role of Neuropeptide Crosstalk from Ventromedial-PACAP to Dorsomedial-Galanin in the Appetite Regulation in the Mouse Hypothalamus. Molecular Neurobiology. 2022
Ryoichi Tashima, Keisuke Koga, Yu Yoshikawa, Misuzu Sekine, Moeka Watanabe, Hidetoshi Tozaki-Saitoh, Hidemasa Furue, Toshiharu Yasaka, Makoto Tsuda. A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior. Proceedings of the National Academy of Sciences. 2021. 118. 3. e2021220118-e2021220118
Taku Nakagawa, Toshiharu Yasaka, Noriyuki Nakashima, Mitsue Takeya, Kensuke Oshita, Makoto Tsuda, Ken Yamaura, Makoto Takano. Expression of the pacemaker channel HCN4 in excitatory interneurons in the dorsal horn of the murine spinal cord. Molecular brain. 2020. 13. 1. 127-127
中川拓, 八坂敏一, 中島則行, 大下健輔, 鷹野誠. マウス脊髄においてHCN4チャネル発現ニューロンはII層からIII層に局在する. 日本生理学雑誌. 2020. 82. 2. 30-31
Kieran A Boyle, Mark A Gradwell, Toshiharu Yasaka, Allen C Dickie, Erika Polgár, Robert P Ganley, Desmond P H Orr, Masahiko Watanabe, Victoria E Abraira, Emily D Kuehn, et al. Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia. Cell reports. 2019. 28. 2. 526-540

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MISC (51)：

中川拓, 中川拓, 大下健輔, 八坂敏一, 中島則行, 鷹野誠, 山浦健. アロディニア病態モデルマウスにおける脊髄後角HCN4陽性興奮性インターニューロンの機能. 日本麻酔科学会学術集会(Web). 2021. 68th
八坂敏一. 脊髄後角局所神経回路の侵害受容信号プロセシング機構. 実験医学. 2020. 38. 3. 401-408
中川拓, 中川拓, 八坂敏一, 中島則行, 大下健輔, 鷹野誠, 山浦健. マウス脊髄後角におけるHCN4チャネル陽性細胞の分布. 日本麻酔科学会学術集会(Web). 2019. 66th
Toshiharu Yasaka. The cellular and synaptic architecture of local circuits in the spinal dorsal horn. Pain Research. 2018. 33. 1. 10-17
Hiroki Yoshida, Tomoko Sasaguri, Asako Ishikawa, Yuzo Murata, Toshiharu Yasaka, Naomi Hirakawa, Hiromitsu Hara. Interleukin 27 controls pain sensitivity in pathophysiological conditions; to immunity and beyond!. CYTOKINE. 2017. 100. 45-45

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Lectures and oral presentations (29)：

Enhanced basal pain sensitivities observed in mice lacking interleukin-27
(9th FAOPS Congress 2019)
Distribution of HCN4 positive cell in mouse spinal dorsal horn
(9th FAOPS Congress 2019)
The Role of IL-27 in Pain due to Hip Osteoarthritis
(Orthopaedic Research Society 2019 Annual Meeting 2019)
Effect of noradrenaline on postsynaptic response facilitated by peripheral mechanical stimulation by an in vivo patch-clamp recording
(Neuroscience 2018 (Society for Neuroscience the 48th Annual Meeting) 2018)
Interleukin 27 controls pain sensitivity in pathophysiological conditions; to immunity and beyond!
(Cytokines 2017 - 5th Annual Meeting of the International Cytokine & Interferon Society 2017)

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Education (3)：

1996 - 2004 Kyushu University
1994 - 1996 Tottori University Graduate School of Medical Sciences
1990 - 1994 Tottori University Faculty of Medicine School of Life Sciences

Professional career (1)：

医学博士 (九州大学)

Work history (5)：

2020/04 - 現在 Niigata University of Health and Welfare Undergraduate School Faculty of Health Sciences Department of Health and Nutrition professor
2016/04 - 2020/03 Kagoshima University Graduate School of Medical and Dental Sciences
2009/07 - 2016/03 Saga University Faculty of Medicine
2006/03 - 2009/06 University of Glasgow Spinal Cord Group Research Assistant
1999/01 - 2001/03 日本学術振興会特別研究員(DC2)

Association Membership(s) (7)：

THE JAPANESE PHARMACOLOGICAL SOCIETY , International Association for the Study of Pain , JAPANESE ASSOCIATION FOR THE STUDY OF MUSCULOSKELETAL PAIN , JAPANESE ASSOCIATION FOR THE STUDY OF PAIN , Society for Neuroscience , THE JAPAN NEUROSCIENCE SOCIETY , THE PHYSIOLOGICAL SOCIETY OF JAPAN

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