2017 - 2020 Establishment of highly safe gene therapy without usage of double stranded DNA
2014 - 2017 Novel animal models for hereditary diseases using human hepatocytes transplanted chimeric mice and vaculovirus
2012 - 2014 Analysis of hepatitis virus genomes using human hepatocytes transplanted chimeric mice and ultra-deep sequencing.
2010 - 2011 Analysis of the relationship between IL28B SNP and HCV genome
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Papers (129)：
Hiromi Abe-Chayama, Takakazu Kawase, Tatsuo Ichinohe, Yuji Ishida, Chise Tateno, Makoto Hijikata, Kazuaki Chayama. Hepatitis B virus-specific human stem cell memory T cells differentiate into cytotoxic T cells and eradicate HBV-infected hepatocytes in mice. FEBS letters. 2024. 598. 11. 1354-1365
Grace Naswa Makokha, Kazuaki Chayama, C Nelson Hayes, Hiromi Abe-Chayama, Maidina Abuduwaili, Makoto Hijikata. Deficiency of SCAP inhibits HBV pathogenesis via activation of the interferon signaling pathway. Virology. 2023. 585. 248-258
Takuro Uchida, Michio Imamura, C Nelson Hayes, Yosuke Suehiro, Yuji Teraoka, Kazuki Ohya, Hiroshi Aikata, Hiromi Abe-Chayama, Yuji Ishida, Chise Tateno, et al. HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice. Hepatology (Baltimore, Md.). 2023
Takuro Uchida, Yuji Teraoka, Michio Imamura, Hiromi Abe-Chayama, Grace Naswa Makokha, Clair Nelson Hayes, Hiroshi Aikata, Satoko Hamamura, Yuji Ishida, Chise Tateno, et al. A novel cDNA-uPA/SCID/Rag2-/- /Jak3-/- mouse model for hepatitis virus infection and reconstruction of human immune system. Journal of viral hepatitis. 2022. 30. 3. 262-272
Yosuke Suehiro, Masataka Tsuge, Mio Kurihara, Takuro Uchida, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Grace Naswa Makokha, Takashi Nakahara, Eisuke Murakami, et al. HBV upregulates TRAIL-R3 expression in hepatocytes for escaping both cell apoptosis and suppression of their replication by TRAIL. The Journal of infectious diseases. 2022
Yuji Teraoka, Michio Imamura, Takuro Uchida, Kazuki Ohya, Mitsutaka Osawa, Kei Morio, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, et al. PERMISSION OF HEPATITIS B VIRUS INFECTION IN Jak3KORag2KO MOUSE. HEPATOLOGY. 2019. 70. 617A-617A
Daiki Miki, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, et al. GENETIC POLYMORPHISM OF IP-10, NOT IFNL4 OR HLA-DPS, AFFECTS LIVER INFLAMMATION IN CHRONIC HEPATITIS B PATIENTS. HEPATOLOGY. 2019. 70. 412A-413A
Daiki Miki, Takashi Nakahara, Eisuke Murakami, Hiromi Abe-Chayama, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, et al. ASSOCIATION OF FNDC5, PNPLA3 AND TM6SF2 POLYMORPHISMS WITH HEPATIC STEATOSIS IN NAFLD PATIENTS. HEPATOLOGY. 2019. 70. 1050A-1051A
Daiki Miki, Yumi Shimomura, Nelson Hayes, Hiromi Abe-Chayama, Hatsue Fujino, Maiko Numba, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Masami Yamauchi, et al. A COMPREHENSIVE ANALYSIS OF A WIDE RANGE OF LIVER DISEASES BY 16S rRNA SEQUENCING REVEALS CHARACTERISTIC PATTERNS OF GUT MICROBIOTA IN EACH ETIOLOGY. HEPATOLOGY. 2019. 70. 1163A-1164A
Daiki Miki, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, et al. INDEPENDENT IMPACT OF POLYMORPHISM IN IRF5 AS WELL AS STAT4 ON HBV-RELATED HEPATOCARCINOGENESIS. HEPATOLOGY. 2019. 70. 1190A-1190A
