Rchr
J-GLOBAL ID:201801021067306975   Update date: Feb. 01, 2024

Kimura Yasuhisa

キムラ ヤスヒサ | Kimura Yasuhisa
Affiliation and department:
Job title: 准教授
Research field  (1): Applied biochemistry
Research keywords  (5): ABCA1 ,  MDR1 ,  high density liposrotein ,  multidrug resistance ,  ABC transporter
Research theme for competitive and other funds  (2):
  • 2023 - 2026 ABCA1による高密度リポ蛋白質(HDL)産生メカニズムの可視化
  • 2022 - 2026 Functional characterization of nascent HDL generation
Papers (56):
  • Hiroshi Tachibana, Kodai Minoura, Tomohiro Omachi, Kohjiro Nagao, Takafumi Ichikawa, Yasuhisa Kimura, Nozomu Kono, Yuta Shimanaka, Hiroyuki Arai, Kazumitsu Ueda, et al. The plasma membrane of focal adhesions has a high content of cholesterol and phosphatidylcholine with saturated acyl chains. Journal of cell science. 2023. 136. 16
  • Atsushi Kodan, Ryota Futamata, Yasuhisa Kimura, Noriyuki Kioka, Toru Nakatsu, Hiroaki Kato, Kazumitsu Ueda. ABCB1/MDR1/P-gp employs an ATP-dependent twist-and-squeeze mechanism to export hydrophobic drugs. FEBS letters. 2021. 595. 6. 707-716
  • Mitsuhiro Nakato, Naoko Shiranaga, Maiko Tomioka, Hitomi Watanabe, Junko Kurisu, Mineko Kengaku, Naoko Komura, Hiromune Ando, Yasuhisa Kimura, Noriyuki Kioka, et al. ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking. Journal of Biological Chemistry. 2021. 296. 100166-100166
  • Kyoko Takata, Tsuyoshi Goto, Mito Kuroda, Yasuhisa Kimura, Ichiro Harada, Kazumitsu Ueda, Teruo Kawada, Noriyuki Kioka. Stiffness of the extracellular matrix regulates differentiation into beige adipocytes. Biochemical and biophysical research communications. 2020. 532. 2. 205-210
  • Ryota Futamata, Fumihiko Ogasawara, Takafumi Ichikawa, Atsushi Kodan, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda. In vivo FRET analyses reveal a role of ATP hydrolysis-associated conformational changes in human P-glycoprotein. Journal of Biological Chemistry. 2020. 295. 15. 5002-5011
more...
MISC (174):
  • 増元亮裕, 木村泰久, 木岡紀幸. A system for transient localization of lipid-modifying enzyme to focal adhesion using chemically induced dimerization. 日本細胞生物学会大会(Web). 2021. 73rd
  • 立花大, 長尾耕治郎, 木村泰久, 木岡紀幸. FA membrane has a specific lipid composition. 日本細胞生物学会大会(Web). 2021. 73rd
  • 鎌田一希, 木村泰久, 木岡紀幸. Purification of Focal Adhesion Protein, Vinexin α using Mammalian Cells. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
  • 小笠原史彦, 岡本雄介, 木村泰久, 木岡紀幸, 木岡紀幸, 植田和光. C-terminus of ABCA1 separately regulates cholesterol-flopping activity and HDL-generating activity. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
  • 増元亮裕, 木村泰久, 木岡紀幸. A system for transient PIP5K localization to focal adhesion using chemically induced dimerization. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
more...
Lectures and oral presentations  (27):
  • Functional relationships between lipids and ABC proteins
    (2020)
  • 生化学的手法を基軸としたヒトABCタンパク質の機能解析
    (第92回 日本生化学会大会 2019)
  • ApoA-I binds to the extracellular domain 1 of human ABCA1
    (60th International Conference on the Bioscience of Lipids(ICBL) 2019)
  • ヒト由来浮遊培養細胞への遺伝子導入手法の検討
    (2018年度日本農芸化学会関西支部大会(第505回講演会) 2018)
  • Substrate entry mechanism of human MDR1
    (7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases 2018)
more...
Education (3):
  • 2002 - 2005 京都大学大学院 農学研究科 応用生命科学専攻 博士後期課程
  • 2000 - 2002 京都大学大学院 農学研究科 応用生命科学専攻 博士前期課程
  • 1996 - 2000 Kyoto University Faculty of Agriculture
Professional career (1):
  • 博士(農学) (京都大学)
Work history (4):
  • 2020/11 - 現在 Kyoto University Graduate School of Agriculture
  • 2007/01 - 2020/10 京都大学大学院 農学研究科 助教
  • 2006/04 - 2006/12 京都大学大学院 薬学研究科 研究員
  • 2005/04 - 2006/03 理化学研究所 播磨研究所 研究員
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page