Kimura Yasuhisa

キムラヤスヒサ | Kimura Yasuhisa

Affiliation and department：
Job title：准教授

Research field (1)： Applied biochemistry

Research keywords (5)： ABCA1 , MDR1 , high density liposrotein , multidrug resistance , ABC transporter

Research theme for competitive and other funds (2)：

Papers (57)：

Kazuki Sakata, Noriyuki Kioka, Kazumitsu Ueda, Yasuhisa Kimura. The ATPase activity of ABCA1 is increased by cholesterol in the presence of anionic lipids. The Journal of Biochemistry. 2024
Hiroshi Tachibana, Kodai Minoura, Tomohiro Omachi, Kohjiro Nagao, Takafumi Ichikawa, Yasuhisa Kimura, Nozomu Kono, Yuta Shimanaka, Hiroyuki Arai, Kazumitsu Ueda, et al. The plasma membrane of focal adhesions has a high content of cholesterol and phosphatidylcholine with saturated acyl chains. Journal of cell science. 2023. 136. 16
Atsushi Kodan, Ryota Futamata, Yasuhisa Kimura, Noriyuki Kioka, Toru Nakatsu, Hiroaki Kato, Kazumitsu Ueda. ABCB1/MDR1/P-gp employs an ATP-dependent twist-and-squeeze mechanism to export hydrophobic drugs. FEBS letters. 2021. 595. 6. 707-716
Mitsuhiro Nakato, Naoko Shiranaga, Maiko Tomioka, Hitomi Watanabe, Junko Kurisu, Mineko Kengaku, Naoko Komura, Hiromune Ando, Yasuhisa Kimura, Noriyuki Kioka, et al. ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking. Journal of Biological Chemistry. 2021. 296. 100166-100166
Kyoko Takata, Tsuyoshi Goto, Mito Kuroda, Yasuhisa Kimura, Ichiro Harada, Kazumitsu Ueda, Teruo Kawada, Noriyuki Kioka. Stiffness of the extracellular matrix regulates differentiation into beige adipocytes. Biochemical and biophysical research communications. 2020. 532. 2. 205-210

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MISC (174)：

増元亮裕, 木村泰久, 木岡紀幸. A system for transient localization of lipid-modifying enzyme to focal adhesion using chemically induced dimerization. 日本細胞生物学会大会(Web). 2021. 73rd
立花大, 長尾耕治郎, 木村泰久, 木岡紀幸. FA membrane has a specific lipid composition. 日本細胞生物学会大会(Web). 2021. 73rd
鎌田一希, 木村泰久, 木岡紀幸. Purification of Focal Adhesion Protein, Vinexin α using Mammalian Cells. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
小笠原史彦, 岡本雄介, 木村泰久, 木岡紀幸, 木岡紀幸, 植田和光. C-terminus of ABCA1 separately regulates cholesterol-flopping activity and HDL-generating activity. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
増元亮裕, 木村泰久, 木岡紀幸. A system for transient PIP5K localization to focal adhesion using chemically induced dimerization. 日本農芸化学会大会講演要旨集(Web). 2021. 2021

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Lectures and oral presentations (27)：

Functional relationships between lipids and ABC proteins
(2020)
生化学的手法を基軸としたヒトABCタンパク質の機能解析
(第92回日本生化学会大会 2019)
ApoA-I binds to the extracellular domain 1 of human ABCA1
(60th International Conference on the Bioscience of Lipids(ICBL) 2019)
ヒト由来浮遊培養細胞への遺伝子導入手法の検討
(2018年度日本農芸化学会関西支部大会(第505回講演会) 2018)
Substrate entry mechanism of human MDR1
(7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases 2018)

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Education (3)：

Professional career (1)：

Work history (4)：

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