Fukushima Hirosh

フクシマヒロシ | Fukushima Hirosh

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Urology

Research theme for competitive and other funds (5)：

2024 - 2026 近赤外光を用いた間質組織リモデリングによる難治性膀胱がんの克服
2019 - 2021 泌尿器癌の癌悪液質におけるサルコペニアの不可逆性の機序の解明と新規治療法の開発
2019 - 2020 サルコペニアが尿路上皮癌における免疫チェックポイント阻害剤の治療効果と腫瘍微小環境に及ぼす影響の解明
2019 - 運動や骨格筋量が尿路上皮癌における免疫チェックポイント阻害剤の治療効果に及ぼす影響の解明 -癌微小環境における免疫ネットワークに着目して-
2015 - 2016 都立病院プロジェクト研究

Papers (132)：

Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Ebaston Thankarajan, Michael P Luciano, Syed Muhammad Usama, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Motofumi Suzuki, et al. Near-infrared duocarmycin photorelease from a Treg-targeted antibody-drug conjugate improves efficacy of PD-1 blockade in syngeneic murine tumor models. OncoImmunology. 2024. 13. 1
Kun Fang, Da-Lang Fang, Hui Yu, Yu-Ang Chen, Pei-Ze Yu, Zi-Fan Wang, Rui-Bin Zhang, Wen Yang, Lei Tao, Hiroshi Fukushima, et al. Exploring the microRNA-mRNA regulatory network associated with solasonine in bladder cancer. Translational Andrology and Urology. 2024. 13. 5. 812-827
Fuyuki F. Inagaki, Makoto Kano, Aki Furusawa, Takuya Kato, Ryuhei Okada, Hiroshi Fukushima, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi. Near-infrared photoimmunotherapy targeting PD-L1: Improved efficacy by preconditioning the tumor microenvironment. Cancer Science. 2024. 115. 7. 2396-2409
Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S. Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L. Choyke, Martin J. Schnermann, Hisataka Kobayashi. Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells. eBioMedicine. 2024. 102. 105050-105050
Hiroshi Fukushima, Seiichiro Takao, Aki Furusawa, Vladimir Valera Romero, Sandeep Gurram, Takuya Kato, Shuhei Okuyama, Makoto Kano, Peter L. Choyke, Hisataka Kobayashi. Near-infrared photoimmunotherapy targeting Nectin-4 in a preclinical model of bladder cancer. Cancer Letters. 2024. 585. 216606-216606

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MISC (17)：

Rie Kato, Hiroshi Fukushima, Toshiki Kijima, Soichiro Yoshida, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Yukihiro Otsuka, Fumitaka Koga, et al. THE QSOFA SCORE OUTPERFORMS THE SIRS SCORE IN PREDICTING IN-HOSPITAL MORTALITY OF OBSTRUCTIVE PYELONEPHRITIS PATIENTS: RESULTS FROM A MULTI-INSTITUTIONAL STUDY. JOURNAL OF UROLOGY. 2020. 203. E677-E677
Fukushima Hiroshi, Takemura Kosuke, Suzuki Hiroaki, Koga Fumitaka. Impact of Sarcopenia as a Prognostic Biomarker of Bladder Cancer. Int J Mol Sci. 2018. 19. 10
Koga Fumitaka, Takemura Kosuke, Fukushima Hiroshi. Biomarkers for Predicting Clinical Outcomes of Chemoradiation-Based Bladder Preservation Therapy for Muscle-Invasive Bladder Cancer. Int J Mol Sci. 2018. 19. 9
Hiroshi Fukushima, Fumitaka Koga. Impact of sarcopenia in the management of urological cancer patients. EXPERT REVIEW OF ANTICANCER THERAPY. 2017. 17. 5. 455-466
Hiroshi Fukushima, Yasukazu Nakanishi, Madoka Kataoka, Ken-ichi Tobisu, Fumitaka Koga. PROGNOSTIC SIGNIFICANCE OF SERUM gamma-GLUTAMYLTRANSFERASE IN ADVANCED UROTHELIAL CARCINOMA PATIENTS. JOURNAL OF UROLOGY. 2017. 197. 4. E433-E434

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Lectures and oral presentations (47)：

SDH染色が陰性であった悪性後腹膜傍神経節腫にSDH欠損腎細胞癌の合併を認めた1例
(2020)
血小板減少と気管支動脈出血をきたした前立腺小細胞癌・骨髄癌腫症に対し早期EP療法が奏功した1例
(第632回日本泌尿器科学会東京地方会 2020)
Pembrolizumab投与で異なる機序による2度の血小板減少を来たした転移性膀胱がんの1例
(第631回日本泌尿器科学会東京地方会 2019)
排尿ケアチームが介入した維持血液透析患者の2例
(第26回日本排尿機能学会 2019)
Impact of bladder neck involvement and positive urine cytology in substratifying intermediate-risk non-muscle-invasive bladder cancer patients based on the prediction of high-risk recurrence.
(113th annual meeting of the American Urological Association 2019)

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Work history (6)：

2024/04 - 現在 Tokyo Medical and Dental University University Hospital of Medicine Assistant Professor
2021/03 - 2024/03 National Institutes of Health Postdoctoral Fellow
2020/01 - 2021/03 Tokyo Medical and Dental University Medical Hospital Hospital Departments Departments of Surgery Urology Assistant Professor
2019/11/01 - 2019/12/31 Tokyo Medical and Dental University Medical Hospital Hospital Departments Departments of Surgery Urology Project Assistant Professor
2019/04/01 - 2019/10/31 Tokyo Medical and Dental University Medical Hospital Hospital Departments Departments of Surgery Urology

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Awards (9)：

2024/10 - 大隅ライフサイエンス研究会大隅ライフサイエンス研究会奨励賞
2024/09 - 東京医科歯科大学統合イノベーション機構イノベーションアイデアコンテスト 2024 最優秀賞
2024/05 - Translational Andrology and Urology 誌 Reviewer of the Month (2024)
2022/09 - Translational Andrology and Urology 誌 Outstanding Author (2022)
2020/01 - 東京医科歯科大学医学研究奨励賞

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