Rchr
J-GLOBAL ID:201801021110434656
Update date: Feb. 13, 2024
Atsushi Tanaka
タナカ アツシ | Atsushi Tanaka
Affiliation and department:
Research field (2):
Tumor diagnostics and therapeutics
, Immunology
Research keywords (6):
免疫自己寛容
, がん免疫
, TCRシグナル分子
, がん免疫療法
, 制御性T細胞 (Treg)
, 自己免疫病
Research theme for competitive and other funds (7):
- 2022 - 2027 Targeting Treg cells in cancer immunotherapy
- 2023 - 2025 次世代がん医療加速化研究事業(P-PROMOTE)
- 2022 - 2023 医療研究開発革新基盤創成事業
- 2017 - 2019 Molecular basis of Treg-specific TCR signaling regulation
- 2015 - 2018 Identification of Genes Controlling Treg Development by Combining the CRISPR-Cas9 System and Bone Marrow Chimeric Mouse Model
- 2014 - 2017 Elucidating the mechanism of autoimmune induction by self-reactive T and regulatory T cells
- 2011 - 2013 ZAP70機能異常による自己免疫発症機序
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Papers (26):
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Christopher Tay, Atsushi Tanaka, Shimon Sakaguchi. Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy. Cancer Cell. 2023. 41. 3. 450-465
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Atsushi Tanaka, Shinji Maeda, Takashi Nomura, Mara Anais Llamas-Covarrubias, Satoshi Tanaka, Lin Jin, Ee Lyn Lim, Hiromasa Morikawa, Yohko Kitagawa, Shuji Akizuki, et al. Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease. Journal of Experimental Medicine. 2023. 220. 2
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Kazunori Yokoi, Rei Watanabe, Miki Kume, Saki Yamane, Atsushi Tanaka, Manabu Fujimoto, Atsushi Tanemura. Melanocyte-specific CD49a + CD8 + T cells in vitiligo lesion potentiate to maintain activity during systemic steroid therapy. The Journal of Dermatology. 2022
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Takuya Sato, Youichi Ogawa, Kazunori Yokoi, Yuka Nagasaka, Aoha Ishikawa, Ichiro Shiokawa, Manao Kinoshita, Rei Watanabe, Shinji Shimada, Atsushi Tanaka, et al. Characterization of human epithelial resident memory regulatory T cells. Frontiers in Immunology. 2022. 13. 962167-962167
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Dean Thumkeo, Siwakorn Punyawatthananukool, Somsak Prasongtanakij, Ryuma Matsuura, Kentaro Arima, Huan Nie, Rie Yamamoto, Naohiro Aoyama, Hisao Hamaguchi, Shingo Sugahara, et al. PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment. Cell Reports. 2022. 39. 10. 110914-110914
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MISC (12):
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河嶋 厚成, 冨山 栄輔, 洪 陽子, 松下 慎, 中野 剛佑, 林 裕次郎, 加藤 大悟, 波多野 浩士, 氏家 剛, 植村 元秀, et al. ニボルマブ抵抗性高悪性度腎細胞癌で高発現する制御性T細胞に特異的な分子CCR8を標的とした新規免疫療法の開発. 日本癌学会総会記事. 2020. 79回. OE14-1
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田中淳. エフェクターTregとがん免疫. 臨床免疫・アレルギー科. 2020. 74. 1. 74-79
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藤岡優樹, 高橋直人, 田中淳. イマチニブによるエフェクター制御性T細胞の除去と抗腫瘍免疫の活性化. 血液内科. 2020. 81. 554-561
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木林達也, 田中淳. ヒトFoxP3+制御性T細胞の多様性とその解析. 臨床免疫・アレルギー科. 2020. 74. 307-313
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田中淳, 坂口志文. Treg特異的なTCRシグナルの分子制御と免疫寛容の維持. 臨床免疫・アレルギー科. 2019. 71. 497-501
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Patents (3):
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新規抗CCR8抗体
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癌治療用医薬組成物
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腫瘍免疫又は感染免疫を増強させる免疫増強剤
Books (1):
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In Chronic Inflammation: Mechanisms and Regulation, K. Takatsu & M. Miyasaka, ed.
Springer, Japan 2016
Lectures and oral presentations (24):
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Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells
(第16回麒麟塾 2021)
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Tregと腫瘍免疫
(Melanoma Conferences 2020)
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Cancer immunotherapy targeting regulatory T cells
(第78回日本癌学会学術総会 2019)
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Treg-specific control of TCR signaling molecules
(Keystone Symposia: Uncovering Mechanisms of Immune-Based Therapy in Cancer and Autoimmunity (B3) 2019)
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制御性T細胞と腫瘍免疫
(Immuno-Checkpoint Blockade Seminar in Osaka 2018 2018)
more...
Education (1):
- - 2009 The University of Chicago, Committee on Immunology (Ph.D.)
Professional career (1):
- Ph.D. (University of Chicago)
Work history (8):
- 2021 - 現在 Immunology Frontier Research Center, Osaka University Associate Professor
- 2021 - 現在 Graduate School of Medicine, Osaka University Associate Professor
- 2014 - 2021 Immunology Frontier Research Center, Osaka University Assistant Professor
- 2014 - 2021 Osaka University Graduate School of Medicine Assistant Professor
- 2011/04 - 2014/03 Institute for Frontier Medical Sciences, Kyoto University JSPS Postdoctoral Research Fellow
- 2009/11 - 2011/03 Kyoto University Institute for Frontier Medical Sciences
- 2009/03 - 2009/07 Abbott Laboratories Cancer Research Department, Abbott Graduate Fellow
- 2001/05 - 2001/08 American Cancer Society Student Cancer Fellow
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Awards (7):
Association Membership(s) (1):
THE JAPANESE SOCIETY FOR IMMUNOLOGY
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