Art

J-GLOBAL ID：201802210871206573   Reference number：18A1715455

Synthesis and antitumor evaluation of novel 4-anilino-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate derivatives as potential EGFR inhibitors

有望なEGFR阻害剤としての新規4-アニリノ-7,8-ジヒドロピリド[4,3-d]ピリミジン-6(5H)-カルボキシラート誘導体の合成と抗腫瘍評価【JST・京大機械翻訳】

Author (7)： Zhang Dajun (Key Laboratory of Behavioral and Cognitive Neuroscience of Liaoning Province, Shenyang Medical College, Shenyang, China) ,  Yan Yan (School of Information Engineering, Liaoning University of Traditional Chinese Medicine, Shenyang, China) ,  Jin Ge (Key Laboratory of Behavioral and Cognitive Neuroscience of Liaoning Province, Shenyang Medical College, Shenyang, China) ,  Liu Bo (Key Laboratory of Behavioral and Cognitive Neuroscience of Liaoning Province, Shenyang Medical College, Shenyang, China) ,  Ma Xiaoliang (Key Laboratory of Behavioral and Cognitive Neuroscience of Liaoning Province, Shenyang Medical College, Shenyang, China) ,  Han Dan (Key Laboratory of Behavioral and Cognitive Neuroscience of Liaoning Province, Shenyang Medical College, Shenyang, China) ,  Jia Xiaojian (Department of Child Psychiatry, Shenzhen Kangning Hospital and Shenzhen Mental Health Center, Shenzhen University Health Science Center, Shenzhen, China)
Material： Archiv der Pharmazie  (Arch Pharm)
Volume： 351  Issue： 9  Page： e1800110  Publication year： 2018 
JST Material Number： A0451A  ISSN： 0365-6233  CODEN： ARPMAS  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Novel series of 4-anilino-7,8-...

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Thesaurus term： cytotoxicity ,  *tumor ,  antitumor action ,  down-regulation ,  enzyme ,  optimization ,  A549 cell ,  EGF receptor ,  phosphorylation ,  in vitro experiment ,  enzymatic analysis
Semi thesaurus term： 抗増殖活性 ,  腫瘍細胞株 ,  *EGFRチロシンキナーゼ阻害剤 , 【Automatic Indexing@JST】

Author keywords (4)： antitumor activity ,  EGFR inhibitors ,  QSAR ,  synthesis

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (6)： EGFR阻害剤 ,  ピリミジン ,  カルボキシラート ,  誘導体 ,  腫瘍 ,  評価