Art

J-GLOBAL ID：201802210980998235   Reference number：18A0480198

Prediction of Apparent Oral Clearance of Small-Molecule Inhibitors in Pediatric Patients

小児患者における小分子阻害剤の見かけの経口クリアランスの予測【Powered by NICT】

Author (8)： Kimura Yoshihiko (Education and Research Center for Clinical Pharmacy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan) ,  Kimura Yoshihiko (Department of Pharmacy, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Kita-ku, Osaka, 530-8480, Japan) ,  Chisaki Yugo (Education and Research Center for Clinical Pharmacy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan) ,  Saki Tomohiko (Education and Research Center for Clinical Pharmacy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan) ,  Matsumura Chikako (Education and Research Center for Clinical Pharmacy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan) ,  Motohashi Hideyuki (Education and Research Center for Clinical Pharmacy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan) ,  Onoue Masahide (Department of Pharmacy, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Kita-ku, Osaka, 530-8480, Japan) ,  Yano Yoshitaka (Education and Research Center for Clinical Pharmacy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan)
Material： Journal of Pharmaceutical Sciences  (J Pharm Sci)
Volume： 107  Issue： 3  Page： 949-956  Publication year： 2018 
JST Material Number： C0260B  ISSN： 0022-3549  CODEN： JPMSAE  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The purpose of this study was ...

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Thesaurus term： modeling ,  regression model ,  *small molecule ,  drug therapy ,  *child ,  *clearance ,  pharmacokinetics ,  allometry ,  error of mean square ,  *child patient
Semi thesaurus term： 予測能力 ,  F値 ,  *阻害剤 ,  *小分子阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： clinical pharmacokinetics ,  pediatric ,  pharmacokinetic/pharmacodynamic models ,  population pharmacokinetics ,  cancer chemotherapy

JST classification (1)： Clinical biopharmacy  (GY01022L)

Terms in the title (4)： 小児患者 ,  小分子阻害剤 ,  経口クリアランス ,  予測