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J-GLOBAL ID：201802213830570708   Reference number：18A1884913

Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning

GPRC5Bの欠損は小脳核ニューロンによるPurkinje細胞のシナプス形成を障害し,小脳シナプスの可塑性と運動学習を破壊する

Author (12)： Sano Takamitsu (Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan) ,  Kohyama-Koganeya Ayako (Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan) ,  Kinoshita Masami O. (Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan) ,  Tatsukawa Tetsuya (Laboratory for Motor Learning Control, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan) ,  Shimizu Chika (Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan) ,  Oshima Eriko (Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan) ,  Yamada Kazuyuki (Support Unit for Animal Resources Development, Research Resources Center, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan) ,  Le Tung Dinh (Laboratory for Motor Learning Control, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan) ,  Akagi Takumi (Support Unit for Animal Resources Development, Research Resources Center, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan) ,  Tohyama Koujiro (Center for Electron Microscopy and Bio-Imaging Research, Iwate Medical University, Morioka, Iwate 020-8505, Japan) ,  Nagao Soichi (Laboratory for Motor Learning Control, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan) ,  Hirabayashi Yoshio (Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan)
Material： Neuroscience Research  (神経科学)
Volume： 136  Page： 33-47  Publication year： Nov. 2018 
JST Material Number： D0210C  ISSN： 0168-0102  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： knockout mouse ,...
Semi thesaurus term： *GPRC5B ,...

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Author keywords (6)： Deep cerebellar nucleus ,  Vestibular nucleus ,  Axonal swelling ,  Mitochondrial dysfunction ,  Synapse formation ,  Motor learning

JST classification (3)： Biological function  (EB03040U) ,  Central nervous system  (EJ12030F) ,  Development(=generation)and differentiation  (EJ16020W)

Terms in the title (11)： 欠損 ,  小脳核 ,  ニューロン ,  Purkinje細胞 ,  シナプス形成 ,  障害 ,  小脳 ,  シナプス ,  可塑性 ,  運動学習 ,  破壊