Art

J-GLOBAL ID：201802213864828911   Reference number：18A1517956

Cyclic analogue of S-benzylisothiourea that suppresses kynurenine production without inhibiting indoleamine 2,3-dioxygenase activity

インドールアミン2,3-ジオキシゲナーゼ活性を阻害しないキヌレニン産生を抑制するS-ベンジルイソチオ尿素の環状類似体【JST・京大機械翻訳】

Author (9)： Fukuda Miwa (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan) ,  Sasaki Tomomi (Laboratory of Medicinal Chemistry, Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano-machi, Hachi-oji, Tokyo 192-0015, Japan) ,  Hashimoto Tomoko (Laboratory of Medicinal Chemistry, Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano-machi, Hachi-oji, Tokyo 192-0015, Japan) ,  Miyachi Hiroyuki (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan) ,  Waki Minoru (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan) ,  Asai Akira (Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan) ,  Takikawa Osamu (National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan) ,  Ohno Osamu (Laboratory of Medicinal Chemistry, Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano-machi, Hachi-oji, Tokyo 192-0015, Japan) ,  Matsuno Kenji (Laboratory of Medicinal Chemistry, Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano-machi, Hachi-oji, Tokyo 192-0015, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 28  Issue： 17  Page： 2846-2849  Publication year： 2018 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Kynurenine is biosynthesised f...

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Thesaurus term： interferon gamma ,  derivatization ,  human(primates) ,  catalyst ,  *dioxygenase ,  *analogical material ,  cyclization reaction ,  enzyme activity ,  biosynthesis ,  amino acid ,  nitrogen heterocyclic compound ,  polynuclear aromatic compound ,  primary amine ,  aromatic amine ,  aromatic ketone ,  diamine
Semi thesaurus term： A431細胞 ,  阻害剤 ,  治療標的 ,  癌治療 , 【Automatic Indexing@JST】

Author keywords (6)： Kynurenine ,  Inhibitor ,  Indoleamine 2 ,  3-Dioxygenase ,  Signal transducer and activator of transcription 1 ,  Immunological cancer treatment

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (2)： Tryptophan ,  Kynurenine

Terms in the title (7)： ジオキシゲナーゼ ,  活性 ,  阻害 ,  キヌレニン ,  S-ベンジルイソチオ尿素 ,  環状 ,  類似体