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J-GLOBAL ID：201802217232662943   Reference number：18A0844825

Effects of FKBP12 and type II BMP receptors on signal transduction by ALK2 activating mutations associated with genetic disorders

遺伝性疾患と関連したALK2活性化変異によるシグナル伝達に対するFKBP12およびII型BMP受容体の影響【JST・京大機械翻訳】

Author (15)： Machiya Aiko (Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan) ,  Machiya Aiko (Division of Orthodontics, Department of Human Development and Fostering, Meikai University School of Dentistry, Saitama, Japan) ,  Tsukamoto Sho (Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan) ,  Tsukamoto Sho (Project of Clinical and Basic Research for FOP, Saitama Medical University, Saitama, Japan) ,  Ohte Satoshi (Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan) ,  Kuratani Mai (Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan) ,  Fujimoto Mai (Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan) ,  Fujimoto Mai (Division of Orthodontics, Department of Human Development and Fostering, Meikai University School of Dentistry, Saitama, Japan) ,  Kumagai Keigo (Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan) ,  Osawa Kenji (Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan) ,  Osawa Kenji (Ivy Dental Clinic, Fukuoka, Japan) ,  Suda Naoto (Division of Orthodontics, Department of Human Development and Fostering, Meikai University School of Dentistry, Saitama, Japan) ,  Bullock Alex N. (Structural Genomics Consortium, University of Oxford, Oxford, UK) ,  Katagiri Takenobu (Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan) ,  Katagiri Takenobu (Project of Clinical and Basic Research for FOP, Saitama Medical University, Saitama, Japan)
Material： Bone (New York)  (Bone (N.Y.))
Volume： 111  Page： 101-108  Publication year： 2018 
JST Material Number： E0177D  ISSN： 8756-3282  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Various substitution mutations...

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Thesaurus term： Mutation ,  modeling ,  osteogenic factor ,  Proteins ,  characterization ,  patient ,  *receptor ,  wild type ,  *hereditary disease ,  interaction ,  serine-threonine kinase ,  repressor ,  overexpression ,  *FK506-binding protein 12 ,  *ALK2

Author keywords (7)： Activin receptor-like kinase 2 (ALK2) ,  Bone morphogenetic proteins (BMPs) ,  Fibrodysplasia ossificans progressiva (FOP) ,  Diffuse intrinsic pontine glioma (DIPG) ,  FKBP12 ,  Signal transduction ,  Heterotopic ossification

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Terms in the title (7)： 遺伝性疾患 ,  ALK2 ,  活性化 ,  変異 ,  シグナル伝達 ,  FKBP12 ,  BMP受容体