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J-GLOBAL ID：201802217338831917   Reference number：18A1850691

Soluble ST2 suppresses IL-5 production by human basophilic KU812 cells, induced by epithelial cell-derived IL-33

可溶性ST2は上皮細胞由来IL-33によって誘導されるヒト好塩基球KU812細胞のIL-5産生を抑制する

Author (7)： Matsumoto Koji (Department of Otorhinolaryngology, Shiga University of Medical Science) ,  Kouzaki Hideaki (Department of Otorhinolaryngology, Shiga University of Medical Science) ,  Kikuoka Hirotaka (Department of Otorhinolaryngology, Shiga University of Medical Science) ,  Kato Tomohisa (Department of Otorhinolaryngology, Shiga University of Medical Science) ,  Tojima Ichiro (Department of Otorhinolaryngology, Shiga University of Medical Science) ,  Shimizu Shino (Department of Otorhinolaryngology, Shiga University of Medical Science) ,  Shimizu Takeshi (Department of Otorhinolaryngology, Shiga University of Medical Science)
Material： Allergology International  (Allergol Int)
Volume： 67  Issue： Supplement.1  Page： S32-S37(J-STAGE)  Publication year： 2018 
JST Material Number： L6446A  ISSN： 1323-8930  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *IL-33 ,...

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Author keywords (10)： Epithelial cell-basophil interaction ,  IL-5 ,  IL-33 ,  Soluble ST2 ,  Th2 cytokine ,  Epithelial cell-basophil interaction ,  IL-5 ,  IL-33 ,  Soluble ST2 ,  Th2 cytokine

JST classification (3)： Immunological reaction in general  (ED03010T) ,  Basic medicine on respiratory system  (GI01020H) ,  Immunologic diseases,allergic diseases in general.  (GD04010C)

Reference (39)：

• 1. Schmitzs J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, et al. IL-33, an interlerukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005;23:479-90.
• 2. Oboki K, Ohno T, Kajiwara N, Saito H, Nakae S. IL-33 and IL-33 receptors in host degense and disease. Allergol Int 2010;59:143-60.
• 3. Divekar R, Kita H. Recent advances in epithelial-derived cytokines (IL-33, IL-25 and TSLP) and allergic inflammation. Curr Opin Allergy Clin Immunol 2015;15:98-103.
• 4. Mueller T, Jaffe AS. Soluble ST2-analytical considerations. Am J Cardiol 2015;115:8B-21.
• 5. Kondo Y, Yoshimoto T, Yasuda K, Futatsugi-Yumikura S, Morimoto M, Hayashi N, et al. Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int Immunol 2008;20:791-800.

Terms in the title (9)： 可溶性 ,  ST2 ,  上皮細胞 ,  IL-33 ,  誘導 ,  ヒト ,  好塩基球 ,  KU812細胞 ,  IL-5