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J-GLOBAL ID：201802217481863292   Reference number：18A1858956

BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells

BCR-ABLチロシンキナーゼ阻害はK562細胞における統合ストレス応答を妨げることにより代謝脆弱性を誘導する【JST・京大機械翻訳】

Author (5)： Kato Yu (Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan) ,  Kato Yu (Division of Chemotherapy, Faculty of Pharmacy, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo, 105-8512, Japan) ,  Kunimasa Kazuhiro (Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan) ,  Sugimoto Yoshikazu (Division of Chemotherapy, Faculty of Pharmacy, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo, 105-8512, Japan) ,  Tomida Akihiro (Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 504  Issue： 4  Page： 721-726  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The integrated stress response...

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Thesaurus term： Pharmacology ,  Phosphatidylinositol 3-Kinase ,  tumorigenesis ,  Proteins ,  *tyrosine kinase ,  Mammalia ,  *Metabolism ,  apoptosis induction ,  tyrosine kinase inhibitor ,  *kinase ,  *stress response ,  Vertebrata ,  enzyme inhibitor
Semi thesaurus term： *脆弱性 , 【Automatic Indexing@JST】

Author keywords (5)： BCR-ABL ,  Integrated stress response ,  PERK ,  GCN2 ,  ATF4

JST classification (2)： Function of cell components  (EF03060C) ,  Cell physiology in general  (EF02010S)

Substance index (3)： Nilotinib ,  Dasatinib ,  Imatinib

Terms in the title (9)： BCR-ABL ,  チロシンキナーゼ ,  阻害 ,  K562細胞 ,  統合 ,  ストレス応答 ,  代謝 ,  脆弱性 ,  誘導