Art

J-GLOBAL ID：201802217636750520   Reference number：18A1802941

Differences in apoptotic signaling and toxicity between dimethylmonothioarsinic acid (DMMTA^V) and its active metabolite, dimethylarsinous acid (DMA^III), in HepaRG cells: Possibility of apoptosis cascade based on diversity of active metabolites of DMMTA^V

Heparg細胞におけるジメチルモノチオアルシン酸(DMMTA V)とその活性代謝物,ジメチル亜アルシン酸(DMA~IIIの間のアポトーシスシグナル伝達と毒性の差異:DMMTA Vの活性代謝産物の多様性に基づくアポトーシスカスケードの可能性【JST・京大機械翻訳】

Author (13)： Shimoda Yasuyo (Laboratory of Environmental Toxicology and Carcinogenesis, Nihon University School of Pharmacy, Chiba 274-8555, Japan) ,  Kato Koichi (Laboratory of Environmental Toxicology and Carcinogenesis, Nihon University School of Pharmacy, Chiba 274-8555, Japan) ,  Asami Satoru (Laboratory of Clinical Medicine, Nihon University School of Pharmacy, Chiba 274-8555, Japan) ,  Kurita Masahiro (Laboratory of Clinical Medicine, Nihon University School of Pharmacy, Chiba 274-8555, Japan) ,  Kurosawa Hidetoshi (Laboratory of Environmental Toxicology and Carcinogenesis, Nihon University School of Pharmacy, Chiba 274-8555, Japan) ,  Kurosawa Hidetoshi (Criminal Investigation Laboratory, Metropolitan Police Department, Tokyo 100-8929, Japan) ,  Toriyama Masaharu (Department of Molecular Chemistry, Nihon University School of Pharmacy, Chiba 274-8555, Japan) ,  Miura Motofumi (Department of Molecular Chemistry, Nihon University School of Pharmacy, Chiba 274-8555, Japan) ,  Hata Akihisa (Department of Medical Risk Management, Graduate School of Risk and Crisis Management, Chiba Institute of Science, Chiba 288-0025, Japan) ,  Endo Yoko (Endo Occupational Health Consultant Office, Osaka 534-0027, Japan) ,  Endo Ginji (Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association, Osaka 550-0001, Japan) ,  An Yan (Department of Toxicology, School of Public Health, Medical College of Soochow University, Suzhou Jiangsu 215123, PR China) ,  Yamanaka Kenzo (Laboratory of Environmental Toxicology and Carcinogenesis, Nihon University School of Pharmacy, Chiba 274-8555, Japan)
Material： Journal of Trace Elements in Medicine and Biology  (J Trace Elem Med Biol)
Volume： 50  Page： 188-197  Publication year： 2018 
JST Material Number： T0779A  ISSN： 0946-672X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Dimethylmonothioarsinical acid...

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Thesaurus term： human(primates) ,  organoarsenic compound ,  cytotoxicity ,  *toxicity ,  lipid ,  characterization ,  hepatocyte ,  *metabolite ,  caspase ,  *apoptosis ,  aliphatic amine ,  thiol ,  aliphatic carboxylic acid ,  tripeptide ,  sulfur containing amino acid
Semi thesaurus term： カスパーゼ9 ,  代謝酵素 ,  肝前駆細胞 , 【Automatic Indexing@JST】

Author keywords (6)： Dimethylmonothioarsinic acid ,  Dimethylarsinous acid ,  Dimethylarsinic acid ,  Apoptosis ,  Caspase ,  Glutathione

JST classification (5)： Influence on animals  (EE05040R) ,  Toxicity of metals and metal compounds  (GZ02022V) ,  Heavy metals and their compounds in general  (SB05021R) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Other pollutants  (SB05040W)

Substance index (2)： Glutathione ,  Dimethylmonothioarsinic acid

Terms in the title (12)： HepaRG細胞 ,  ジメチルモノチオアルシン酸 ,  活性代謝物 ,  ジメチル亜アルシン酸 ,  アポトーシス ,  シグナル伝達 ,  毒性 ,  差異 ,  活性 ,  代謝産物 ,  多様性 ,  可能性