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J-GLOBAL ID：201802217708481023   Reference number：18A0025052

A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs

AMPKのための非常に感度の高いFRETバイオセンサ細胞と器官の間の異種のAMPK応答を示す【Powered by NICT】

Author (12)： Konagaya Yumi (Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan) ,  Terai Kenta (Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan) ,  Hirao Yusuke (Department of Medical Science, Graduate School of Medicine, University of Hiroshima, Hiroshima 734-8553, Japan) ,  Takakura Kanako (Imaging Platform for Spatio-Temporal Regulation, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan) ,  Imajo Masamichi (Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan) ,  Kamioka Yuji (Department of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Osaka 570-8506, Japan) ,  Sasaoka Norio (Laboratory of Functional Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan) ,  Kakizuka Akira (Laboratory of Functional Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan) ,  Sumiyama Kenta (Laboratory for Mouse Genetic Engineering, Quantitative Biology Center, RIKEN, Osaka 565-0874, Japan) ,  Asano Tomoichiro (Department of Medical Science, Graduate School of Medicine, University of Hiroshima, Hiroshima 734-8553, Japan) ,  Matsuda Michiyuki (Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan) ,  Matsuda Michiyuki (Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan)
Material： Cell Reports
Volume： 21  Issue： 9  Page： 2628-2638  Publication year： 2017 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： AMP-activated protein kinase (...

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Thesaurus term： interaction ,  hypoglycemic drug ,  inactivation ,  in vitro experiment ,  *biosensor ,  high sensitivity ,  analogical material ,  transgenic mouse ,  Type 2 diabetes mellitus ,  cell metabolism ,  *AMP-Activated Protein Kinases ,  STK11 protein ,  aliphatic amine ,  nitrogen heterocyclic compound ,  ribonucleotide ,  carboxamide ,  aminocarboxylic acid
Semi thesaurus term： LKB1 , 【Automatic Indexing@JST】

Author keywords (10)： fluorescence resonance energy transfer ,  FRET ,  AMP-activated protein kinase ,  AMPK ,  liver kinase B1 ,  LKB1 ,  peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 ,  Pin1 ,  cell metabolism ,  live imaging

JST classification (4)： Cell physiology in general  (EF02010S) ,  Function of cell components  (EF03060C) ,  Basic medicine on cardiovascular system  (GJ01020K) ,  Enzyme physiology  (EJ02020P)

Substance index (2)： Metformin ,  AICAR

Terms in the title (7)： AMPK ,  感度 ,  FRET ,  バイオセンサ ,  細胞 ,  器官 ,  応答