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J-GLOBAL ID：201802217794134255   Reference number：18A0420605

Multiple myeloma cells adapted to long-exposure of hypoxia exhibit stem cell characters with TGF-β/Smad pathway activation

低酸素の学長時間露光に適応した多発性骨髄腫細胞はTGF-β/Smad経路活性化と幹細胞特性を示す【Powered by NICT】

Author (10)： Nakagawa Yoko (Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan) ,  Ashihara Eishi (Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan) ,  Ashihara Eishi (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Yao Hisayuki (Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan) ,  Yokota Asumi (Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan) ,  Toda Yuki (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Miura Yasuo (Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan) ,  Nakata Susumu (Department of Clinical Oncology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Hirai Hideyo (Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan) ,  Maekawa Taira (Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 496  Issue： 2  Page： 490-496  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The emergence of new molecular...

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Thesaurus term： adaptability ,  mRNA ,  *bone marrow ,  *multiple myeloma ,  *oxygen deficiency ,  carcinogenicity ,  *TGF beta ,  clone ,  *stem cell ,  phosphorylation ,  molecular targeting drug
Semi thesaurus term： *ミエローマ ,  過剰発現 ,  自己複製 ,  *Smad蛋白質 , 【Automatic Indexing@JST】

Author keywords (6)： Multiple myeloma ,  Bone marrow microenvironment ,  Hypoxia ,  Myeloma stem cells ,  TGF-β ,  Smad2

JST classification (2)： Gene expression  (EC02040Q) ,  Function of cell components  (EF03060C)

Terms in the title (10)： 低酸素 ,  露光 ,  適応 ,  多発性骨髄腫 ,  細胞 ,  TGF-β ,  SMAD ,  経路 ,  活性化 ,  幹細胞