Art

J-GLOBAL ID：201802220509584991   Reference number：18A1197026

Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma

喘息のマウスモデルにおける気道炎症と過敏性に対するレチノイドX受容体部分作動薬の効果【JST・京大機械翻訳】

Author (12)： Fujii Utako (Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan) ,  Miyahara Nobuaki (Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan) ,  Taniguchi Akihiko (Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan) ,  Oda Naohiro (Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan) ,  Morichika Daisuke (Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan) ,  Murakami Etsuko (Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan) ,  Nakayama Hikari (Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan) ,  Waseda Koichi (Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan) ,  Kataoka Mikio (Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan) ,  Kakuta Hiroki (Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan) ,  Tanimoto Mitsune (Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan) ,  Kanehiro Arihiko (Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan)
Material： Respiratory Research (Web)
Volume： 18  Issue： 1  Page： 23  Publication year： 2017 
JST Material Number： U7545A  ISSN： 1465-993X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Background Retinoid X receptor...

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Thesaurus term： egg albumin ,  nitrogen monoxide ,  sensitization (immunology) ,  *retinoid X receptor ,  allergic disease ,  *air duct (respiration) ,  NF-kappaB ,  allergen ,  vitamin A ,  oral administration ,  *asthma ,  Goblet Cells ,  *mouse model
Semi thesaurus term： 気道過敏性 ,  *気道炎症 , 【Automatic Indexing@JST】

Author keywords (6)： Asthma ,  RXR ,  RXR partial agonist ,  NF-κB ,  Nitric oxide ,  Animal model

JST classification (5)： Immunological reaction in general  (ED03010T) ,  Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Vitamin A  (EB07020A) ,  Receptors on cell membrane  (EF04030C) ,  Basic medicine on respiratory system  (GI01020H)

Reference (44)：

• N Engl J Med; Asthma; WW Busse, RF Lemanske; 344; 2001; 350-362; 10.1056/NEJM200102013440507; CR1;
• J Allergy Clin Immunol; Pulmonary T cells and eosinophils: coconspirators or independent triggers of allergic respiratory pathology?; NA Lee, EW Gelfand, JJ Lee; 107; 2001; 945-957; 10.1067/mai.2001.116002; CR2;
• Pharmacol Rev; International Union of Pharmacology. LXIII. Retinoid X receptors; P Germain, P Chambon, G Eichele, RM Evans, MA Lazar, M Leid, AR Lera, R Lotan, DJ Mangelsdorf, H Gronemeyer; 58; 2006; 760-772; 10.1124/pr.58.4.7; CR3;
• Cell; The nuclear receptor superfamily: the second decade; DJ Mangelsdorf, C Thummel, M Beato, P Herrlich, G Schutz, K Umesono, B Blumberg, P Kastner, M Mark, P Chambon, RM Evans; 83; 1995; 835-839; 10.1016/0092-8674(95)90199-X; CR4;
• Cell; Structural determinants of allosteric ligand activation in RXR heterodimers; AI Shulman, C Larson, DJ Mangelsdorf, R Ranganathan; 116; 2004; 417-429; 10.1016/S0092-8674(04)00119-9; CR5;

Terms in the title (6)： 喘息 ,  マウスモデル ,  気道炎症 ,  過敏性 ,  レチノイドX受容体 ,  部分作動薬