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J-GLOBAL ID：201802220861326175   Reference number：18A0256351

Structural pharmacological studies on EGFR T790M/C797S

EGFR T790M/C797Sの構造薬理学的研究【Powered by NICT】

Author (19)： Kong Lu-Lu (Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Kong Lu-Lu (Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Kong Lu-Lu (Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Ma Rui (Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Ma Rui (Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Ma Rui (Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Yao Ming-Yu (Fengnan District Hospital, Tangshan 063300, China) ,  Yan Xiao-E. (Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Yan Xiao-E. (Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Yan Xiao-E. (Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Zhu Su-Jie (Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Zhu Su-Jie (Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Zhu Su-Jie (Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Zhao Peng (Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Zhao Peng (Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Zhao Peng (Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Yun Cai-Hong (Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Yun Cai-Hong (Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Yun Cai-Hong (Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 488  Issue： 2  Page： 266-272  Publication year： 2017 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Drug-resistance is a major cha...

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Thesaurus term： *Pharmacology ,  wild type ,  non-small cell lung cancer ,  enzyme kinetics ,  molecular target therapy ,  irreversibility ,  Drug Resistance ,  covalent bond ,  crystal structure ,  hydrophilicity ,  *EGF receptor ,  Drug Discovery ,  kinase ,  Genetic Variation
Semi thesaurus term： variation(biology) ,  阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： EGFR ,  T790M ,  C797S ,  Drug-resistance ,  Go6976

JST classification (2)： Cell physiology in general  (EF02010S) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (3)： EGFR ,  薬理学 ,  研究