Art

J-GLOBAL ID：201802220939222817   Reference number：18A0709031

Engineered U7 snRNA mediates sustained splicing correction in erythroid cells from β-thalassemia/HbE patients

遺伝子操作U7 snRNAはβサラセミア/HBe患者由来赤血球細胞における持続的スプライシング補正を仲介する【JST・京大機械翻訳】

Author (11)： Preedagasamzin Sarinthip (Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand) ,  Nualkaew Tiwaporn (Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand) ,  Pongrujikorn Tanjitti (Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand) ,  Pongrujikorn Tanjitti (Program in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand) ,  Jinawath Natini (Program in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand) ,  Jinawath Natini (Integrative Computational Bioscience Center, Mahidol University, Nakhon Pathom, Thailand) ,  Kole Ryszard (Ercole Consulting, Chapel Hill, NC 27514, USA) ,  Fucharoen Suthat (Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand) ,  Jearawiriyapaisarn Natee (Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand) ,  Svasti Saovaros (Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand) ,  Svasti Saovaros (Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 499  Issue： 1  Page： 86-92  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Repair of a splicing defect of...

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Thesaurus term： *Thalassemia ,  *patient ,  Gene Therapy ,  Mutation ,  targeting ,  globin ,  mRNA ,  *gene manipulation ,  Pathology ,  vector (genetics) ,  Up-Regulation ,  *erythrocyte ,  *snRNA ,  Erythroid Precursor Cell ,  Lentiviral vector

Author keywords (5)： Thalassemia ,  HbE ,  U7 snRNA ,  RNA splicing ,  Gene therapy

JST classification (1)： Gene manipulation  (EC02050B)

Terms in the title (8)： 遺伝子操作 ,  snRNA ,  βサラセミア ,  患者 ,  赤血球 ,  細胞 ,  スプライシング ,  仲介