Art

J-GLOBAL ID：201802221630992364   Reference number：18A1381191

Inter-individual Variability in Activity of the Major Drug Metabolizing Enzymes in Liver Homogenates of 20 Individuals

20人の肝臓ホモジネートにおける主要薬物代謝酵素活性の個体間変動【JST・京大機械翻訳】

Author (10)： den Braver-Sewradj Shalenie P. (AIMMS-Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ Amsterdam, Netherlands) ,  den Braver Michiel W. (AIMMS-Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ Amsterdam, Netherlands) ,  van Dijk Marc (AIMMS-Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ Amsterdam, Netherlands) ,  Zhang Yongjie (AIMMS-Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ Amsterdam, Netherlands) ,  Dekker Stefan J. (AIMMS-Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ Amsterdam, Netherlands) ,  Wijaya Lukas (AIMMS-Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ Amsterdam, Netherlands) ,  Vermeulen Nico P.E. (AIMMS-Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ Amsterdam, Netherlands) ,  Richert Lysiane (Kaly-Cell, 20A Rue du General Leclerc, Plobsheim, France) ,  Commandeur Jan N.M. (AIMMS-Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ Amsterdam, Netherlands) ,  Vos J. Chris (AIMMS-Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ Amsterdam, Netherlands)
Material： Current Drug Metabolism
Volume： 19  Issue： 4  Page： 370-381  Publication year： 2018 
JST Material Number： W3583A  ISSN： 1389-2002  Document type： Article
Article type： 原著論文  Country of issue： Unknown (ARE)  Language： ENGLISH (EN)

Abstract/Point： Background: Inter-individual v...

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Thesaurus term： glutathione transferase ,  simultaneous determination ,  rate theory ,  clearance ,  *enzyme activity ,  cytosol ,  cytochrome P450 ,  *drug metabolizing enzyme ,  UDP glucuronosyltransferase ,  *drug metabolism ,  modeling ,  fatty acid ,  aromatic amine ,  phenolic compound ,  carboxamide ,  aminoalcohol
Semi thesaurus term： アイソフォーム ,  in silico ,  *ホモジネート , 【Automatic Indexing@JST】

Author keywords (6)： Inter-individual variability ,  drug metabolizing enzymes ,  correlations ,  phase I metabolism ,  phase II metabolism ,  reaction phenotyping.

JST classification (4)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Enzyme physiology  (EJ02020P) ,  Basic biopharmacy  (GY01021U) ,  Liver  (EJ06060J)

Substance index (1)： Acetaminophen

Terms in the title (5)： 肝臓 ,  ホモジネート ,  薬物代謝酵素 ,  活性 ,  個体