Art
J-GLOBAL ID：201802222117394427   Reference number：18A0275113

BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib

BRAF変異のある細胞はベムラフェニブに対する応答における細胞保護機構としてのGCN2を介した統合されたストレス応答を活性化する【Powered by NICT】
Author (6)：
Nagasawa Ikuko

About Nagasawa Ikuko

(Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan)

About Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan

, 
Nagasawa Ikuko

About Nagasawa Ikuko

(Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan)

About Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan

, 
Kunimasa Kazuhiro

About Kunimasa Kazuhiro

(Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan)

About Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan

, 
Tsukahara Satomi

About Tsukahara Satomi

(Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan)

About Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan

, 
Tomida Akihiro

About Tomida Akihiro

(Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan)

About Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan

, 
Tomida Akihiro

About Tomida Akihiro

(Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan)

About Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan


Material：
Biochemical and Biophysical Research Communications  (BBRC)

About Biochemical and Biophysical Research Communications


Volume： 482  Issue： 4  Page： 1491-1497  Publication year： 2017 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
All summary is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
In BRAF-mutated melanoma cells...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
endoplasmic reticulum

About endoplasmic reticulum

, 
siRNA

About siRNA

, 
ER stress

About ER stress

, 
phosphorylation

About phosphorylation

, 
gene silencing

About gene silencing

, 
melanoma

About melanoma

, 
amino acid

About amino acid

, 
drug resistance

About drug resistance

, 
*variation(biology)

About variation(biology)

, 
protein kinase

About protein kinase

, 
enzyme inhibitor

About enzyme inhibitor

, 
molecular targeting drug

About molecular targeting drug


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
キナーゼ

About キナーゼ

, 
eIF2α

About eIF2α

, 
*ストレス応答

About ストレス応答

, 
*GCN2キナーゼ

About GCN2キナーゼ

, 【Automatic Indexing@JST】
Author keywords (5)：
Vemurafenib

About Vemurafenib

, 
BRAF

About BRAF

, 
Integrated stress response

About Integrated stress response

, 
GCN2

About GCN2

, 
ATF4

About ATF4

JST classification (4)：
JST classification
Category name(code) classified by JST.
Cell physiology in general 
(EF02010S)

About Cell physiology in general

,  Carcinogenic mechanisms and factors 
(GE02020C)

About Carcinogenic mechanisms and factors

,  Biological function 
(EB03040U)

About Biological function

,  Microorganism physiology in general 
(EG03051L)

About Microorganism physiology in general

Substance index (1)：
Substance index
Chemical Substance indexed to the Article.
Vemurafenib

About Vemurafenib

Terms in the title (10)：
Terms in the title
Keywords automatically extracted from the title.
BRAF

About BRAF

, 
変異

About 変異

, 
細胞

About 細胞

, 
ベムラフェニブ

About ベムラフェニブ

, 
応答

About 応答

, 
細胞保護

About 細胞保護

, 
GCN2

About GCN2

, 
統合

About 統合

, 
ストレス応答

About ストレス応答

, 
活性化

About 活性化


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