Art

J-GLOBAL ID：201802222942394991   Reference number：18A0236477

A carbon 21 steroidal metabolite from progestin, 20β-hydroxy-5α-dihydroprogesterone, stimulates the androgen receptor in prostate cancer cells

20β-ヒドロキシ-5α-ジヒドロプロゲステロン,プロゲスチンからの炭素21種のステロイド代謝産物は前立腺癌細胞におけるアンドロゲン受容体を刺激する【Powered by NICT】

Author (6)： Ando Takashi (Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan) ,  Nishiyama Tsutomu (Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan) ,  Takizawa Itsuhiro (Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan) ,  Miyashiro Yoshimichi (ASKA Pharmaceutical Medical Co. Ltd., Kawasaki, Kanagawa, Japan) ,  Hara Noboru (Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan) ,  Tomita Yoshihiko (Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan)
Material： Prostate
Volume： 78  Issue： 3  Page： 222-232  Publication year： 2018 
JST Material Number： T0088A  ISSN： 0270-4137  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： BACKGROUND: Clarifying the mec...

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Thesaurus term： Cell Proliferation ,  glucocorticoid receptor ,  *prostatic tumor ,  *androgen receptor ,  *Metabolism ,  *male sex hormone ,  enzyme ,  wild type ,  gene expression ,  incubate ,  enzyme antibody technique ,  LNCaP cell ,  *Steroid metabolism ,  *gestagen ,  molecular genetic phenomenon ,  bioassay ,  ketone ,  steroid ,  olefin compound ,  alicyclic alcohol ,  secondary alcohol

Author keywords (4)： androgen receptor ,  progestin ,  prostate cancer ,  steroidal metabolism

JST classification (3)： Receptors on cell membrane  (EF04030C) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Urogenital tumors(=neoplasms)  (GM04000S)

Substance index (1)： Pregnenolone

Terms in the title (7)： プロゲスチン ,  炭素 ,  ステロイド ,  代謝産物 ,  前立腺癌細胞 ,  アンドロゲン受容体 ,  刺激