Art

J-GLOBAL ID：201802223621579871   Reference number：18A1785526

Transducin β-like 1, X-linked and nuclear receptor co-repressor cooperatively augment the ligand-independent stimulation of TRH and TSHβ gene promoters by thyroid hormone receptors

トランスデューシンβ様1,X連鎖,および核受容体共レプレッサーは甲状腺ホルモン受容体によるTRH及びTSHβ遺伝子プロモーターのリガンド非依存性刺激を協同的に増強する

Author (20)： Takamizawa Tetsuya (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Satoh Tetsurou (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Miyamoto Tomoko (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Nakajima Yasuyo (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Ishizuka Takahiro (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Tomaru Takuya (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Yoshino Satoshi (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Katano-Toki Akiko (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Nishikido Ayaka (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Sapkota Santosh (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Watanabe Takuya (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Okamura Takashi (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Ishida Emi (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Horiguchi Kazuhiko (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Matsumoto Syunichi (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Ishii Sumiyasu (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Ozawa Atsushi (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Shibusawa Nobuyuki (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Okada Shuichi (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Yamada Masanobu (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan)
Material： Endocrine Journal (Web)
Volume： 65  Issue： 8  Page： 805-813(J-STAGE)  Publication year： 2018 
JST Material Number： U1479A  ISSN： 1348-4540  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： coupling factor ,...

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Author keywords (6)： Central hypothyroidism ,  Transducin β-like 1 ,  X-linked ,  Co-repressor ,  TRH ,  TSHβ

JST classification (3)： Basic medicine on endocrine system  (GL01020Q) ,  Biological function  (EB03040U) ,  Genetic variation  (EC01030Y)

Reference (22)：

• 1 Yamada M, Mori M (2008) Mechanisms related to the pathophysiology and management of central hypothyroidism. Nat Clin Pract Endocrinol Metab 4: 638-694.
• 2 Collu R, Tang J, Castagne J, Lagace G, Masson N, et al. (1997) A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene. J Clin Endocr Metab 82: 1561-1565.
• 3 Sun Y, Bak B, Schoenmakers N, van Trotsenburg AS, Oostdijk W, et al. (2012) Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement. Nat Genet 44: 1375-1381.
• 4 Yamada M, Saga Y, Shibusawa N, Hirato J, Murakami M, et al. (1997) Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene. Proc Natl Acad Sci U S A 94: 10862-10867.
• 5 Yamada M, Shibusawa N, Ishii S, Horiguchi K, Umezawa R, et al. (2006) Prolactin secretion in mice with thyrotropin-releasing hormone deficiency. Endocrinology 147: 2591-2596.

Terms in the title (12)： トランスデューシン ,  核受容体 ,  レプレッサー ,  甲状腺ホルモン受容体 ,  TRH ,  TSH ,  遺伝子プロモーター ,  リガンド ,  非依存性 ,  刺激 ,  協同 ,  増強