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J-GLOBAL ID：201802224078718383   Reference number：18A1850763

Activation of the AKT Pathway in the Ascending Aorta With Bicuspid Aortic Valve

二尖大動脈弁を有する上行大動脈におけるAkt経路の活性化

Author (9)： Hirata Yuichiro (Division of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine) ,  Aoki Hiroki (Cardiovascular Research Institute, Kurume University) ,  Shojima Takahiro (Division of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine) ,  Takagi Kazuyoshi (Division of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine) ,  Takaseya Tohru (Division of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine) ,  Akasu Kohji (Division of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine) ,  Tobinaga Satoru (Division of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine) ,  Fukumoto Yoshihiro (Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine) ,  Tanaka Hiroyuki (Division of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine)
Material： Circulation Journal  (Circ J)
Volume： 82  Issue： 10  Page： 2485-2492(J-STAGE)  Publication year： 2018 
JST Material Number： F0908A  ISSN： 1346-9843  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Aortic Valve Stenosis ,...
Semi thesaurus term： *Aortic stenosis of bicuspid valve ,...

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Author keywords (3)： AKT ,  Bicuspid aortic valve ,  Transcriptome

JST classification (1)： Clinical medicine on cardiovascular system in general  (GJ01030V)

Reference (27)：

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• 3. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SOR/STS/SVM Guidelies for the Diagnosis and Management of Patients With Thoracic Aortic Disease Representative Members, Hiratzka LF, Creager MA, Isselbacher EM, Svensson LG, 2014 AHA/ACC Guidelin for the Management of Patients With Valvular Heart Disease Representative Members, et al. Surgery for aortic dilatation in patients with bicuspid aortic valves: A statement of clarification from the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Thorac Cardiovasc Surg 2016; 151: 959-966.
• 4. Nathan DP, Xu C, Plappert T, Desjardins B, Gorman JH 3rd, Bavaria JE, et al. Increased ascending aortic wall stress in patients with bicuspid aortic valves. Ann Thorac Surg 2011; 92: 1384-1389.
• 5. Vergara C, Viscardi F, Antiga L, Luciani GB. Influence of bicuspid valve geometry on ascending aortic fluid dynamics: A parametric study. Artif Organs 2012; 36: 368-378.

Terms in the title (5)： 大動脈弁 ,  上行大動脈 ,  AKT ,  経路 ,  活性化