Art

J-GLOBAL ID：201802224755628073   Reference number：18A1103201

Leptin Aggravates Reflux Esophagitis by Increasing Tissue Levels of Macrophage Migration Inhibitory Factor in Rats

レプチンはラットにおけるマクロファージ遊走阻止因子の組織レベルの増加により逆流性食道炎を悪化させる

Author (11)： Murata Tsugihiro (Division of Gastroenterology, Tohoku University Graduate School of Medicine) ,  Asanuma Kiyotaka (Division of Gastroenterology, Tohoku University Graduate School of Medicine) ,  Ara Nobuyuki (Division of Gastroenterology, Tohoku University Graduate School of Medicine) ,  Iijima Katsunori (Department of Gastroenterology and Neurology, Akita University Graduate School of Medicine) ,  Hatta Waku (Division of Gastroenterology, Tohoku University Graduate School of Medicine) ,  Hamada Shin (Division of Gastroenterology, Tohoku University Graduate School of Medicine) ,  Asano Naoki (Division of Gastroenterology, Tohoku University Graduate School of Medicine) ,  Koike Tomoyuki (Division of Gastroenterology, Tohoku University Graduate School of Medicine) ,  Imatani Akira (Division of Gastroenterology, Tohoku University Graduate School of Medicine) ,  Masamune Atsushi (Division of Gastroenterology, Tohoku University Graduate School of Medicine) ,  Shimosegawa Tooru (Division of Gastroenterology, Tohoku University Graduate School of Medicine)
Material： Tohoku Journal of Experimental Medicine  (Tohoku J Exp Med)
Volume： 245  Issue： 1  Page： 45-53(J-STAGE)  Publication year： 2018 
JST Material Number： G0649A  ISSN： 0040-8727  CODEN： TJEMAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *leptin ,...
Semi thesaurus term： cellular signal transduction ,...

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Author keywords (5)： CD3+ T lymphocytes ,  leptin ,  macrophage migration inhibitory factor ,  obesity ,  reflux esophagitis

JST classification (2)： Basic medicine on digestive system  (GH01020E) ,  Cytokines  (EB08090G)

Reference (33)：

• Barbier, M., Attoub, S., Joubert, M., Bado, A., Laboisse, C., Cherbut, C. & Galmiche, J.P. (2001) Proinflammatory role of leptin in experimental colitis in rats benefit of cholecystokinin-B antagonist and beta3-agonist. <i>Life Sci.</i>, 69, 567-580.
• Busso, N., So, A., Chobaz-Peclat, V., Morard, C., Martinez-Soria, E., Talabot-Ayer, D. & Gabay, C. (2002) Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. <i>J. Immunol.</i>, 168, 875-882.
• Calandra, T. & Roger, T. (2003) Macrophage migration inhibitory factor: a regulator of innate immunity. <i>Nat. Rev. Immunol.</i>, 3, 791-800.
• Carino, C., Olawaiye, A.B., Cherfils, S., Serikawa, T., Lynch, M.P., Rueda, B.R. & Gonzalez, R.R. (2008) Leptin regulation of proangiogenic molecules in benign and cancerous endometrial cells. <i>Int. J. Cancer</i>, 123, 2782-2790.
• Chua, S.C. Jr., Koutras, I.K., Han, L., Liu, S.M., Kay, J., Young, S.J., Chung, W.K. & Leibel, R.L. (1997) Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. <i>Genomics</i>, 45, 264-270.

Terms in the title (6)： レプチン ,  ラット ,  マクロファージ遊走阻止因子 ,  組織 ,  逆流性食道炎 ,  悪化