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J-GLOBAL ID：201802225019006412   Reference number：18A1980788

Animal experiments to reveal the mechanism of BBB permeability enhanced by t-PA

t-PA のBBB 透過性亢進のメカニズムに迫ってきた各種動物実験

Author (1)： SUZUKI YASUHIRO (奥羽大学薬学部)
Material： 日本血栓止血学会誌  (Japanese Journal of Thrombosis and Hemostasis)
Volume： 29  Issue： 5  Page： 461-464(J-STAGE)  Publication year： 2018 
JST Material Number： L2757A  ISSN： 0915-7441  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *t-PA ,...
Semi thesaurus term： *recombinant t-PA ,...

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Author keywords (10)： tissue-type plasminogen activator ,  ischemic stroke ,  blood-brain barrier ,  ischemic reperfusion injury ,  vascular endothelial growth factor ,  tissue-type plasminogen activator ,  ischemic stroke ,  blood-brain barrier ,  ischemic reperfusion injury ,  vascular endothelial growth factor

JST classification (1)： Basic research of drugs acting on blood and body fluid  (GW14010M)

Reference (23)：

• 1) Ohmori C, Sakai Y, Matano Y, Suzuki Y, Umemura K, Nagai N: Increase in blood-brain barrier permeability does not directly induce neuronal death but may accelerate ischemic neuronal damage. Exp Anim doi: 10.1538/expanim.18-0038, 2018.
• 2) Nour M, Scalzo F, Liebeskind DS: Ischemia-reperfusion injury in stroke. Interv Neurol 1: 185-199, 2013.
• 3) Jickling GC, Liu D, Stamova B, Ander BP, Zhan X, Lu A, Sharp FR: Hemorrhagic transformation after ischemic stroke in animals and humans. J Cereb Blood Flow Metab 34: 185-199, 2014.
• 4) Rogove AD, Tsirka SE: Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus. Curr Biol 8: 19-25, 1998.
• 5) Suzuki Y, Nagai N, Umemura K, Collen D, Lijnen HR: Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice. J Thromb Haemost 5:1732-1739, 2007.

Terms in the title (5)： 透過性 ,  亢進 ,  メカニズム ,  動物 ,  実験