Art

J-GLOBAL ID：201802226063250243   Reference number：18A0490372

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity

オレキシン1受容体拮抗薬YNT707の必須構造:オレキシン1受容体きっ抗活性に及ぼす14 ヒドロキシ基の劇的効果【Powered by NICT】

Author (13)： Ohrui Sayaka (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Yamamoto Naoshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Saitoh Tsuyoshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Kutsumura Noriki (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Nagumo Yasuyuki (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Irukayama-Tomobe Yoko (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Ogawa Yasuhiro (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Ishikawa Yukiko (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Watanabe Yurie (School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan) ,  Hayakawa Daichi (School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan) ,  Gouda Hiroaki (School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan) ,  Yanagisawa Masashi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Nagase Hiroshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 28  Issue： 4  Page： 774-777  Publication year： 2018 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The 14-dehydration- and 14-H d...

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Thesaurus term： affinity ,  *receptor ,  sulfonamide ,  steric conformation ,  *antagonism ,  side chain ,  dewatering ,  *hydroxy group ,  conformational search ,  *Orexins
Semi thesaurus term： アンタゴニスト ,  *受容体拮抗薬 , 【Automatic Indexing@JST】

Author keywords (5)： Orexin ,  OX1R antagonist ,  YNT-707 ,  45-Epoxymorphinan ,  Conformational study

JST classification (1)： Structure-activity relationship of drugs  (GV01050B)

Terms in the title (6)： オレキシン ,  受容体拮抗薬 ,  受容体 ,  きっ抗 ,  活性 ,  ヒドロキシ基