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J-GLOBAL ID：201802226472781155   Reference number：18A0975319

Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene

不均一なリボ核蛋白質A3(hnRNP A3)はC9orf72遺伝子の伸長に関連する前頭側頭葉変性と運動ニューロン疾患における封入体を含むジペプチド反復蛋白質に存在する【JST・京大機械翻訳】

Author (18)： Davidson Yvonne S. (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Salford Royal Hospital, Salford, UK) ,  Flood Louis (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Salford Royal Hospital, Salford, UK) ,  Robinson Andrew C. (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Salford Royal Hospital, Salford, UK) ,  Nihei Yoshihiro (Biomedical Centre (BMC), Biochemistry, Ludwig-Maximilians Universitat Munchen, Munich, Germany) ,  Mori Kohji (Biomedical Centre (BMC), Biochemistry, Ludwig-Maximilians Universitat Munchen, Munich, Germany) ,  Mori Kohji (Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Rollinson Sara (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK) ,  Richardson Anna (Cerebral Function Unit, Greater Manchester Neurosciences Centre, Salford Royal Hospital, Salford, UK) ,  Benson Bridget C. (Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square Brain Bank for Neurological Disorders, London, UK) ,  Jones Matthew (Cerebral Function Unit, Greater Manchester Neurosciences Centre, Salford Royal Hospital, Salford, UK) ,  Snowden Julie S. (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Salford Royal Hospital, Salford, UK) ,  Snowden Julie S. (Cerebral Function Unit, Greater Manchester Neurosciences Centre, Salford Royal Hospital, Salford, UK) ,  Pickering-Brown Stuart (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK) ,  Haass Christian (Biomedical Centre (BMC), Biochemistry, Ludwig-Maximilians Universitat Munchen, Munich, Germany) ,  Haass Christian (German Centre for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany) ,  Haass Christian (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ,  Lashley Tammaryn (Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square Brain Bank for Neurological Disorders, London, UK) ,  Mann David M. A. (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Salford Royal Hospital, Salford, UK)
Material： Acta Neuropathologica Communications (Web)
Volume： 5  Issue： 1  Page： 31  Publication year： 2017 
JST Material Number： U7296A  ISSN： 2051-5960  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Frontotemporal Lobar Degenerat...

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Thesaurus term： pathology ,  cerebellum ,  immunostaining ,  immunological reaction ,  *inclusion body ,  genetics ,  quantitative analysis(analytical chemistry) ,  *neuron ,  patient ,  pathogenesis ,  variation(biology)
Semi thesaurus term： TDP-43 ,  *ヘテロ核リボ核蛋白質 ,  神経変性疾患 ,  前頭側頭葉変性症 , 【Automatic Indexing@JST】

Author keywords (5)： Frontotemporal Lobar Degeneration ,  Motor neuron disease ,  Heterogeneous ribonuclear proteins ,  C9orf72 gene ,  Dipeptide repeat proteins

JST classification (2)： Nervous system diseases  (GN03000O) ,  Basic neurology  (GN01020W)

Reference (34)：

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• Neurobiol Aging; Analysis of hnRNPA1, A2/B1, and A3 genes in patients with amyotrophic lateral sclerosis; D Calini, L Corrado, R Bo, S Gagliardi, V Pensato, F Verde, S Corti, L Mazzini, P Milani, B Castellotti, C Bertolin, G Sorarù, C Cereda, GP Comi, S D'Alfonso, C Gellera, N Ticozzi, JE Landers, A Ratti, V Silani; 34; 2013; 2695.e11-2; 10.1016/j.neurobiolaging.2013.05.025; CR5;

Terms in the title (11)： リボ核蛋白質 ,  hnRNP ,  C9orf72遺伝子 ,  前頭 ,  側頭葉 ,  変性 ,  運動ニューロン疾患 ,  封入体 ,  ジペプチド ,  反復 ,  蛋白質