Art

J-GLOBAL ID：201802226710950636   Reference number：18A1803381

One-pot enzymatic synthesis of l-[3-¹¹C]lactate for pharmacokinetic analysis of lactate metabolism in rat brain

ラット脳における乳酸代謝の薬物動態解析のためのL-[3-11C]乳酸のワンポット酵素的合成【JST・京大機械翻訳】

Author (10)： Temma Takashi (Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan) ,  Temma Takashi (Department of Biofunctional Analysis, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Kawashima Hidekazu (Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan) ,  Kawashima Hidekazu (Radioisotope Research Center, Kyoto Pharmaceutical University, 1 Misasagi-Shichono-cho, Yamashina-ku, Kyoto 607-8412, Japan) ,  Kondo Naoya (Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan) ,  Kondo Naoya (Department of Biofunctional Analysis, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Yamazaki Makoto (Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan) ,  Yamazaki Makoto (Department of Medical & General Sciences, Faculty of Health Sciences, Nihon Institute of Medical Science, 1276 Shimogawara, Moroyamamachi, Irumagun, Saitama 350-0435, Japan) ,  Koshino Kazuhiro (Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan) ,  Iida Hidehiro (Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan)
Material： Nuclear Medicine and Biology  (Nucl Med Biol)
Volume： 64-65  Page： 28-33  Publication year： 2018 
JST Material Number： D0652A  ISSN： 0969-8051  CODEN： NMBIEO  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Lactate could serve as an ener...

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Thesaurus term： catalase ,  high performance liquid chromatography ,  precursor (substance) ,  Fasting ,  *pharmacokinetics ,  metabolite ,  insulin ,  pretreatment ,  Methylation ,  PET (tomography) ,  probe ,  purity ,  *Rattus ,  intravenous administration ,  peroxidase ,  hypoglycemic drug ,  metabolic drug ,  carbohydrate metabolic drug ,  drug ,  *Myomorpha ,  aliphatic alcohol ,  aliphatic carboxylic acid ,  secondary alcohol ,  hydroxy acid

Author keywords (6)： l-[3-¹¹C]Lactate ,  One-pot enzymatic synthesis ,  PET ,  Rat ,  Brain ,  Metabolite

JST classification (4)： NMR of organic compounds  (BM07044Q) ,  Other phsical analysis  (CC03014E) ,  Nuclear chemistry,radiochemistry in general  (CB10010V) ,  Vitamin B group  (EB07030L)

Substance index (1)： Lactic acid

Terms in the title (8)： ラット ,  脳 ,  乳酸 ,  代謝 ,  薬物動態 ,  解析 ,  ポット ,  酵素的合成