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J-GLOBAL ID：201802228011869378   Reference number：18A0577931

Elimination of eosinophils using anti-IL-5 receptor alpha antibodies effectively suppresses IL-33-mediated pulmonary arterial hypertrophy

抗IL-5受容体α抗体を用いた好酸球の除去はIL-33仲介肺動脈肥大を効果的に抑制する【Powered by NICT】

Author (10)： Ikutani Masashi (Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan) ,  Ikutani Masashi (Department of Immune Regulation, The Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba, Japan) ,  Ogawa Shinya (R&D Division, Tokyo Research Park, Kyowa Hakko Kirin Co. Ltd, Tokyo, Japan) ,  Yanagibashi Tsutomu (Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan) ,  Yanagibashi Tsutomu (Toyama Prefectural Institute for Pharmaceutical Research, Toyama, Japan) ,  Nagai Terumi (Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan) ,  Okada Kazuki (R&D Division, Tokyo Research Park, Kyowa Hakko Kirin Co. Ltd, Tokyo, Japan) ,  Furuichi Yoko (R&D Division, Tokyo Research Park, Kyowa Hakko Kirin Co. Ltd, Tokyo, Japan) ,  Takatsu Kiyoshi (Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan) ,  Takatsu Kiyoshi (Toyama Prefectural Institute for Pharmaceutical Research, Toyama, Japan)
Material： Immunobiology
Volume： 223  Issue： 6-7  Page： 486-492  Publication year： 2018 
JST Material Number： W1632A  ISSN： 0171-2985  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Interleukin (IL)-5 is a critic...

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Thesaurus term： chimeric antibody ,  asthma ,  *antibody ,  human(primates) ,  *receptor ,  allergic reaction ,  *eosinophils ,  clinical trial ,  *pulmonary artery ,  ADCC ,  *interleukin 5 ,  immunotherapy ,  monoclonal antibody ,  chimera
Semi thesaurus term： 動物モデル , 【Automatic Indexing@JST】

Author keywords (5)： Interleukin-5 ,  Interleukin-33 ,  Eosinophil ,  Immunotherapy ,  Pulmonary arterial hypertrophy

JST classification (1)： Basic medicine on respiratory system  (GI01020H)

Terms in the title (8)： IL-5 ,  受容体 ,  抗体 ,  好酸球 ,  IL-33 ,  仲介 ,  肺動脈 ,  肥大