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J-GLOBAL ID：201802228105164817   Reference number：18A0267837

Investigation of the inhibitory mechanism of apomorphine against MDM2-p53 interaction

MDM2-p53相互作用に対するアポモルフィンの阻害機構の研究【Powered by NICT】
Author (9)：
Ishiba Hiroyuki

About Ishiba Hiroyuki

(Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan)

About Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan

, 
Noguchi Taro

About Noguchi Taro

(Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan)

About Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan

, 
Shu Keitou

About Shu Keitou

(Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan)

About Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan

, 
Ohno Hiroaki

About Ohno Hiroaki

(Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan)

About Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan

, 
Honda Kaori

About Honda Kaori

(Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan)

About Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan

, 
Kondoh Yasumitsu

About Kondoh Yasumitsu

(Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan)

About Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan

, 
Osada Hiroyuki

About Osada Hiroyuki

(Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan)

About Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan

, 
Fujii Nobutaka

About Fujii Nobutaka

(Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan)

About Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan

, 
Oishi Shinya

About Oishi Shinya

(Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan)

About Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan


Material：
Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)

About Bioorganic & Medicinal Chemistry Letters


Volume： 27  Issue： 11  Page： 2571-2574  Publication year： 2017 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
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Mirror-image screening using d...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
natural material

About natural material

, 
enantiomer

About enantiomer

, 
*interaction

About interaction

, 
*p53 protein

About p53 protein

, 
screening (inspection)

About screening (inspection)

, 
covalent bond

About covalent bond

, 
achiral

About achiral

, 
inhibitory activity

About inhibitory activity

, 
chirality

About chirality

, 
enantiomorphism

About enantiomorphism

, 
*inhibition mechanism

About inhibition mechanism

, 
*mdm2 protein

About mdm2 protein

, 
nitrogen heterocyclic compound

About nitrogen heterocyclic compound

, 
aporphine alkaloid

About aporphine alkaloid

, 
polyphenol

About polyphenol

, 
polynuclear aromatic compound

About polynuclear aromatic compound


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
阻害剤

About 阻害剤

, 
薬物スクリーニング

About 薬物スクリーニング

, 【Automatic Indexing@JST】
Author keywords (6)：
MDM2

About MDM2

, 
p53

About p53

, 
Mirror-image screening

About Mirror-image screening

, 
Apomorphine

About Apomorphine

, 
Oxoapomorphine

About Oxoapomorphine

, 
Michael acceptor

About Michael acceptor

JST classification (2)：
JST classification
Category name(code) classified by JST.
Synthesis of drugs 
(GV01030F)

About Synthesis of drugs

,  Peptides 
(CF10080G)

About Peptides

Substance index (1)：
Substance index
Chemical Substance indexed to the Article.
Apomorphine

About Apomorphine

Terms in the title (6)：
Terms in the title
Keywords automatically extracted from the title.
MDM2

About MDM2

, 
p53

About p53

, 
相互作用

About 相互作用

, 
アポモルフィン

About アポモルフィン

, 
阻害

About 阻害

, 
研究

About 研究


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