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J-GLOBAL ID：201802228421039551   Reference number：18A0124701

Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616

カルモジュリン依存性蛋白質キナーゼII(CaMKII)はセリン616でのダイナミン関連蛋白質1(Drp1)のリン酸化を調節することによる放射線誘発ミトコンドリア分裂を仲介する【Powered by NICT】

Author (6)： Bo Tomoki (Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan) ,  Yamamori Tohru (Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan) ,  Suzuki Motofumi (Radiation and Cancer Biology Team, National Institutes for Quantum and Radiobiological Science and Technology, Chiba, Japan) ,  Sakai Yuri (Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan) ,  Yamamoto Kumiko (Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan) ,  Inanami Osamu (Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 495  Issue： 2  Page： 1601-1607  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Mitochondrial dynamics are sug...

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Thesaurus term： *Mitochondria ,  *phosphorylation ,  radioactive ray ,  wild type ,  X-ray irradiation ,  Calmodulin ,  ionizing radiation ,  quality ,  necessary condition ,  *Proteins ,  *protein kinase ,  reconstitution ,  *mitochondrial fission ,  *Drp1 ,  *Calcium-Calmodulin-Dependent Protein Kinase Type 2

Author keywords (5)： CaMKII ,  Drp1 ,  Ionizing radiation ,  Mitochondrial dynamics ,  Phosphorylation

JST classification (2)： Cell physiology in general  (EF02010S) ,  Function of cell components  (EF03060C)

Terms in the title (13)： カルモジュリン ,  依存性 ,  蛋白質キナーゼ ,  CaMKII ,  セリン ,  ダイナミン関連蛋白質1 ,  Drp1 ,  リン酸化 ,  調節 ,  放射線 ,  誘発 ,  ミトコンドリア分裂 ,  仲介