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J-GLOBAL ID：201802228861605964   Reference number：18A1026892

Early Seizures Prematurely Unsilence Auditory Synapses to Disrupt Thalamocortical Critical Period Plasticity

早期発作は視床皮質臨界周期可塑性を破壊するために聴覚シナプスを未熟に抑制する【JST・京大機械翻訳】

Author (8)： Sun Hongyu (Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Sun Hongyu (Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada) ,  Takesian Anne E. (F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA 02115, USA) ,  Wang Ting Ting (Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada) ,  Lippman-Bell Jocelyn J. (Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Hensch Takao K. (F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA 02115, USA) ,  Hensch Takao K. (Center for Brain Science, Department of Molecular & Cellular Biology, Harvard University, 52 Oxford St., Cambridge, MA 02138, USA) ,  Jensen Frances E. (Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA)
Material： Cell Reports
Volume： 23  Issue： 9  Page： 2533-2540  Publication year： 2018 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Heightened neural excitability...

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Thesaurus term： sensitivity ,  characterization ,  Auditory Cortex ,  *auditory sense ,  *plasticity ,  autism ,  Gene Silencing ,  NMDA receptor ,  *synapse ,  *seizure (disease) ,  AMPA receptor ,  Epilepsy ,  therapy ,  cortex ,  *mechanical property ,  *property
Semi thesaurus term： 治療標的 ,  アンタゴニスト , 【Automatic Indexing@JST】

Author keywords (10)： epilepsy ,  development ,  tonotopic plasticity ,  auditory cortex ,  AMPA receptor ,  NMDA receptor ,  NBQX ,  silent synapses ,  autism ,  neurodevelopmental disorders

JST classification (2)： Central nervous system  (EJ12030F) ,  Receptors on cell membrane  (EF04030C)

Terms in the title (9)： 早期 ,  発作 ,  視床皮質 ,  臨界 ,  周期 ,  可塑性 ,  破壊 ,  聴覚 ,  シナプス