Art

J-GLOBAL ID：201802229473479424   Reference number：18A0946565

Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence

遅い代謝型のADH1Bとヘテロ欠損型ALDH2はアルコール依存症の日本人男性において脂肪肝の罹患率を上昇させる

Author (8)： YOKOYAMA Akira (National Hospital Organization Kurihama Medical and Addiction Center, Kanagawa, JPN) ,  TANIKI Nobuhito (Keio Univ. School of Medicine, Tokyo, JPN) ,  HARA Sachiko (National Hospital Organization Kurihama Medical and Addiction Center, Kanagawa, JPN) ,  HAYSASHI Emiko (National Hospital Organization Kurihama Medical and Addiction Center, Kanagawa, JPN) ,  NAKAMOTO Nobuhiro (Keio Univ. School of Medicine, Tokyo, JPN) ,  MIZUKAMI Takeshi (National Hospital Organization Kurihama Medical and Addiction Center, Kanagawa, JPN) ,  MARUYAMA Katsuya (National Hospital Organization Kurihama Medical and Addiction Center, Kanagawa, JPN) ,  YOKOYAMA Tetsuji (National Inst. of Public Health, Saitama, JPN)
Material： Journal of Gastroenterology  (J Gastroenterol)
Volume： 53  Issue： 5  Page： 660-669  Publication year： 2018 
JST Material Number： Z0748A  ISSN： 0944-1174  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： ADH1B gene ,...

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JST classification (1)： Digestive system diseases  (GH03000W)

Reference (54)：

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• Yokoyama A, Tsutsumi E, Imazeki H, et al. Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men. Int J Cancer. 2007;121:1047-54.

Terms in the title (8)： 代謝 ,  欠損 ,  ALDH2 ,  アルコール依存症 ,  日本人 ,  男性 ,  脂肪肝 ,  罹患率