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J-GLOBAL ID：201802230267430292   Reference number：18A0234866

Unique anti-myeloma activity by thiazolidine-2,4-dione compounds with Pim inhibiting activity

Pim阻害活性を有するチアゾリジン 2,4 ジオン化合物によるユニークな抗ミエローマ活性【Powered by NICT】

Author (21)： Fujii Shiro (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Nakamura Shingen (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Oda Asuka (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Miki Hirokazu (Division of Transfusion Medicine and Cell Therapy, Tokushima University hospital, Tokushima, Japan) ,  Tenshin Hirofumi (Department of Orthodontics and Dentofacial Orthopaedics, Tokushima University Graduate School, Tokushima, Japan) ,  Teramachi Jumpei (Department of Histology and Oral Histology, Tokushima University Graduate School, Tokushima, Japan) ,  Hiasa Masahiro (Department of Biomaterials and Bioengineerings, Tokushima University Graduate School, Tokushima, Japan) ,  Bat-Erdene Ariunzaya (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Maeda Yusaku (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Oura Masahiro (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Takahashi Mamiko (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Iwasa Masami (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Endo Itsuro (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Yoshida Sumiko (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Aihara Ken-ichi (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Kurahashi Kiyoe (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Harada Takeshi (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Kagawa Kumiko (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan) ,  Nakao Michiyasu (Department of Molecular Medicinal Chemistry, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan) ,  Sano Shigeki (Department of Molecular Medicinal Chemistry, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan) ,  Abe Masahiro (Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School, Tokushima, Japan)
Material： British Journal of Haematology  (Br J Haematol)
Volume： 180  Issue： 2  Page： 246-258  Publication year： 2018 
JST Material Number： C0969B  ISSN： 0007-1048  CODEN： BJHEAL  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Proviral Integrations of Molon...

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Thesaurus term： *multiple myeloma ,  ubiquitin ,  tumorigenesis ,  clone ,  virus ,  mRNA ,  enzyme inhibitor ,  molecular targeting drug
Semi thesaurus term： プロテアソーム阻害剤 ,  コロニー形成 ,  乳癌耐性蛋白質 ,  細胞生存 ,  阻害剤 ,  治療標的 ,  過剰発現 ,  ウイルス組込み , 【Automatic Indexing@JST】

Author keywords (6)： multiple myeloma ,  PIM2 ,  thiazolidine-2 ,  4-dione compounds ,  breast cancer resistance protein ,  proteasome inhibitor

JST classification (5)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Experimental treatment for tumors  (GE02040Y) ,  Blood cell tumors(=neoplasms)  (GK04000M) ,  Basic oncology in general  (GE02010R) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (1)： Carfilzomib

Terms in the title (6)： PIM ,  阻害活性 ,  チアゾリジン ,  ジオン ,  ミエローマ ,  活性