Art

J-GLOBAL ID：201802230394719393   Reference number：18A1758328

Proton Affinitive Derivatization for Highly Sensitive Determination of Testosterone and Dihydrotestosterone in Saliva Samples by LC-ESI-MS/MS

LC-ESI-MS/MSによる唾液試料中のテストステロンとジヒドロテストステロンの高感度定量のためのプロトン親和性誘導体化

Author (5)： OHNO Ken-ichi (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  HASEGAWA Tomomi (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  TAMURA Tomomi (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  UTSUMI Haruka (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  YAMASHITA Kouwa (Yokohama University of Pharmacy)
Material： Analytical Sciences  (Anal Sci)
Volume： 34  Issue： 9  Page： 1017-1021(J-STAGE)  Publication year： 2018 
JST Material Number： G0673B  ISSN： 0910-6340  CODEN： ANSCEN  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *LC-MS analysis ,  *Electrospray Ionization Mass Spectrometry ,  *tandem mass spectrometry ,  *saliva ,  *quantitative analysis(analytical chemistry) ,  high sensitivity ,  *proton affinity ,  *derivatization ,  matrix effect ,  suppression and control ,  *carboxylic acid ,  *nitrogen heterocyclic compound ,  esterification ,  isotope ,  reversed phase chromatography ,  chemical synthesis ,  steroid ,  alicyclic alcohol ,  alicyclic ketone ,  enone ,  aliphatic amine ,  tertiary amine
Semi thesaurus term： *LC-ESI-MS/MS ,  ion suppression ,  *Picolinic Acids

Author keywords (6)： Proton affinitive derivatization ,  picolinic acid analog ,  LC-MS/MS ,  saliva sample ,  matrix effect ,  ion suppression

JST classification (3)： Physical analysis of organic compounds  (CC03034A) ,  Chromatography and electrophoretic analysis of organic compounds  (CC04034H) ,  Steroids  (CF10040O)

Substance index (17)： 3-Methylpicolinic acid ,  4-(Dimethylamino)pyridine ,  Dihydrotestosterone ,  Fusaric acid ,  6-Methylpicolinic acid ,  Testosterone ,  Triethylamine ,  Picolinic acid ,  Bis(2-methyl-6-nitrobenzoic acid)anhydride ,  3-Oxoandrosta-4-ene-17β-ol 2-pyridinecarboxylate ,  (1S,3aS,3bR,5aS,9aS,9bS,11aS)-9a,11a-dimethyl-7-oxo-tetradecahydrocyclopenta[a]phenanthren-1-yl pyridine-2-carboxylate ,  3-Oxoandrosta-4-ene-17β-ol 3-methyl-2-pyridinecarboxylate ,  (1S,3aS,3bR,5aS,9aS,9bS,11aS)-9a,11a-dimethyl-7-oxo-tetradecahydrocyclopenta[a]phenanthren-1-yl 3-methylpyridine-2-carboxylate ,  (1S,3aS,3bR,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,8H,9H,9bH,10H,11H-cyclopenta[a]phenanthren-1-yl 6-methylpyridine-2-carboxylate ,  (1S,3aS,3bR,5aS,9aS,9bS,11aS)-9a,11a-dimethyl-7-oxo-tetradecahydrocyclopenta[a]phenanthren-1-yl 6-methylpyridine-2-carboxylate ,  (1S,3aS,3bR,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,8H,9H,9bH,10H,11H-cyclopenta[a]phenanthren-1-yl 5-butylpyridine-2-carboxylate ,  (1S,3aS,3bR,5aS,9aS,9bS,11aS)-9a,11a-dimethyl-7-oxo-tetradecahydrocyclopenta[a]phenanthren-1-yl 5-butylpyridine-2-carboxylate

Reference (37)：

• 1. N. Bruchovsky and J. D. Wilson, Steroids, 1999, 64, 753.
• 2. J. M. Torres and E. Ortega, J. Mol. Endocrinol., 2006, 36, 239.
• 3. M. Grah, Proc. Natl. Acad. Sci., 2003, 100, 7859.
• 4. G. Bartsch, R. S. Rittmaster, and M. Klocker, Eur. Urol., 2000, 37, 367.
• 5. R. Ghanadian and C. M. Puah, J. Endocrinol., 1981, 88, 255.

Terms in the title (9)： LC-ESI-MS ,  唾液 ,  試料 ,  テストステロン ,  ジヒドロテストステロン ,  高感度 ,  定量 ,  プロトン親和性 ,  誘導体化