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J-GLOBAL ID：201802230841131867   Reference number：18A2242428

SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent manner

SIRT1ノックダウンはデアセチラーゼ非依存的に腎臓腺癌細胞のp53およびp21/cip1発現をアップレギュレートするが,正常な腎臓由来細胞ではアップレギュレートしない

Author (4)： Fujino Tomofumi (Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan) ,  Yokokawa Rina (Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan) ,  Oshima Toshiyuki (Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan) ,  Hayakawa Makio (Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 43  Issue： 12  Page： 711-715(J-STAGE)  Publication year： 2018 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *histone deacetylase ,...
Semi thesaurus term： ACHN cell ,...

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Author keywords (4)： SIRT1 ,  Deacetylase-independent ,  Cyclin-dependent kinase inhibitor ,  Carcinoma-specific cytotoxicity

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Gene expression  (EC02040Q)

Reference (8)：

• el-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W. and Vogelstein, B. (1993): WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817-825.
• Fujino, T., Yokosuka, A., Higurashi, H., Yokokawa, R., Sakurai, R., Harashima, W., Miki, Y., Fujiwara, Y., Mimaki, Y. and Hayakawa, M. (2017): AU-1 from Agavaceae plants causes transient increase in p21/Cip1 expression in renal adenocarcinoma ACHN cells in an miR-34-dependent manner. J. Nat. Med., 71, 36-43.
• Jang, M.J., Park, U.H., Kim, J.W., Choi, H., Um, S.J. and Kim, E.J. (2017): CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis. Cell Death Dis., 8, 3201.
• Kim, D.H., Jung, Y.J., Lee, J.E., Lee, A.S., Kang, K.P., Lee, S., Park, S.K., Han, M.K., Lee, S.Y., Ramkumar, K.M., Sung, M.J. and Kim, W. (2011): SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53. Am. J. Physiol. Renal Physiol., 301, F427-F435.
• Oka, S., Alcendor, R., Zhai, P., Park, J.Y., Shao, D., Cho, J., Yamamoto, T., Tian, B. and Sadoshima, J. (2011): PPARα-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway. Cell Metab., 14, 598-611.

Terms in the title (11)： SIRT1 ,  ノックダウン ,  デアセチラーゼ ,  非依存 ,  腎臓 ,  腺癌細胞 ,  p53 ,  p21 ,  CIP1 ,  発現 ,  細胞