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J-GLOBAL ID：201802231738376995   Reference number：18A0928319

Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity

TET1コンパクト触媒ドメインに対して選択されたチオエーテル大環状ペプチドはTET1触媒活性を阻害する【JST・京大機械翻訳】

Author (11)： Nishio Kosuke (Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Belle Roman (Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK) ,  Katoh Takayuki (Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Kawamura Akane (Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK) ,  Kawamura Akane (Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Welcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK) ,  Sengoku Toru (RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, 230-0045, Japan) ,  Hanada Kazuharu (Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan) ,  Ohsawa Noboru (Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan) ,  Shirouzu Mikako (Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan) ,  Yokoyama Shigeyuki (RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, 230-0045, Japan) ,  Suga Hiroaki (Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan)
Material： ChemBioChem
Volume： 19  Issue： 9  Page： 979-985  Publication year： 2018 
JST Material Number： W1258A  ISSN： 1439-4227  CODEN： CBCHFX  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The ten-eleven translocation (...

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Thesaurus term： oxidation ,  *catalytic activity ,  gene expression ,  translocation (genetics) ,  affinity ,  demethylation ,  binding site ,  *cyclopeptide ,  DNA Methylation ,  genomic DNA ,  isoform ,  *Catalytic Domain ,  *Methylcytosine dioxygenase TET1 ,  molecular genetic phenomenon ,  cellular genetic phenomenon
Semi thesaurus term： 阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： DNA demethylation ,  library design ,  inhibitors ,  macrocycles ,  peptides

JST classification (2)： Applications of enzymes  (EB09100B) ,  Proteins and peptides in general  (EB03010N)

Substance index (1)： 5-Methylcytosine

Terms in the title (7)： TET1 ,  コンパクト ,  触媒ドメイン ,  チオエーテル ,  環状ペプチド ,  触媒活性 ,  阻害