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J-GLOBAL ID：201802232111207898   Reference number：18A0590790

Mutations at multiple CDK phosphorylation consensus sites on Cdt2 increase the affinity of CRL4^Cdt2 for PCNA and its ubiquitination activity in S phase

Cdt2上の複数のCDKリン酸化コンセンサス部位での変異はS期におけるPCNAとそのユビキチン化活性に対するCRL4^Cdt2の親和性を増加させる

Author (6)： Nukina Kohei (Graduate School of Life Science, University of Hyogo, Ako, Hyogo, Japan) ,  Hayashi Akiyo (Graduate School of Life Science, University of Hyogo, Ako, Hyogo, Japan) ,  Shiomi Yasushi (Graduate School of Life Science, University of Hyogo, Ako, Hyogo, Japan) ,  Sugasawa Kaoru (Biosignal Research Center, Kobe University, Kobe, Japan) ,  Ohtsubo Motoaki (Department of Food and Fermentation Science, Faculty of Food Science and Nutrition, Beppu University, Beppu, Oita, Japan) ,  Nishitani Hideo (Graduate School of Life Science, University of Hyogo, Ako, Hyogo, Japan)
Material： Genes to Cells  (Genes Cells)
Volume： 23  Issue： 3  Page： 200-213  Publication year： Mar. 2018 
JST Material Number： W0935A  ISSN： 1356-9597  CODEN： GECEFL  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *cyclin-dependent kinase ,...
Semi thesaurus term： variation(biology) ,...

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Author keywords (7)： CDK ,  Cdt2 ,  cell cycle ,  DNA replication ,  PCNA ,  proteolysis ,  ubiquitin

JST classification (4)： Cell division and proliferation  (EF02020D) ,  Function of cell components  (EF03060C) ,  Animal biochemistry  (EJ01050P) ,  Enzyme physiology  (EJ02020P)

Terms in the title (9)： cdk ,  リン酸化 ,  コンセンサス ,  変異 ,  S期 ,  PCNA ,  ユビキチン化 ,  活性 ,  親和性