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J-GLOBAL ID：201802232331259916   Reference number：18A0487761

Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum

プログラニュリンSort1への逆行性シグナル伝達は発生中の小脳におけるシナプス除去を妨げる【Powered by NICT】

Author (14)： Uesaka Naofumi (Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Abe Manabu (Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan) ,  Konno Kohtarou (Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan) ,  Yamazaki Maya (Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan) ,  Sakoori Kazuto (Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Watanabe Takaki (Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Watanabe Takaki (International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo 113-0033, Japan) ,  Kao Tzu-Huei (Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Kao Tzu-Huei (International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo 113-0033, Japan) ,  Mikuni Takayasu (Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Watanabe Masahiko (Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan) ,  Sakimura Kenji (Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan) ,  Kano Masanobu (Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Kano Masanobu (International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo 113-0033, Japan)
Material： Neuron
Volume： 97  Issue： 4  Page： 796-805.e5  Publication year： 2018 
JST Material Number： T0649A  ISSN： 0896-6273  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Elimination of redundant synap...

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Thesaurus term： *Cerebellum ,  multiplex ,  neonate ,  Purkinje Cells ,  *synapse ,  growth factor ,  pathogenesis ,  joint (part) ,  receptor ,  Semaphorin-3A ,  Post-natal development ,  Climbing fiber ,  *Progranulin ,  *Brain
Semi thesaurus term： 多機能 ,  前頭側頭型認知症 , 【Automatic Indexing@JST】

Author keywords (10)： progranulin ,  Sort1 ,  synapse elimination ,  cerebellum ,  climbing fiber ,  Purkinje cell ,  postnatal development ,  retrograde signal ,  frontotemporal dementia ,  mouse

JST classification (2)： Central nervous system  (EJ12030F) ,  Basic neurology  (GN01020W)

Terms in the title (4)： プログラニュリン ,  シグナル伝達 ,  小脳 ,  シナプス