Art

J-GLOBAL ID：201802232624214614   Reference number：18A1289896

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

グルタチオンS-トランスフェラーゼP1はHepG2細胞においてアモジアキンキノンイミン誘導細胞毒性を保護するが小胞体ストレスの活性化を防止しない【JST・京大機械翻訳】

Author (9)： Zhang Yongjie (Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam) ,  Zhang Yongjie (Clinical Pharmacokinetics Research Laboratory, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University) ,  den Braver-Sewradj Shalenie P. (Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam) ,  den Braver Michiel W. (Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam) ,  Hiemstra Steven (Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University) ,  Vermeulen Nico P. E. (Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam) ,  van de Water Bob (Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University) ,  Commandeur Jan N. M. (Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam) ,  Vos J. C. (Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam)
Material： Frontiers in Pharmacology (Web)
Volume： 9  Page： 388  Publication year： 2018 
JST Material Number： U7091A  ISSN： 1663-9812  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Formation of the reactive amod...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A1289896&from=J-GLOBAL&jstjournalNo=U7091A") }}

Thesaurus term： apoptosis ,  oxidative stress ,  antimalarial drug ,  *glutathione transferase ,  image processing ,  conjugation(metabolism) ,  inflammation ,  *cytotoxicity ,  DNA lesion ,  *HepG2 cell ,  protective action ,  human(primates) ,  aliphatic amine ,  thiol ,  aliphatic carboxylic acid ,  tripeptide ,  sulfur containing amino acid
Semi thesaurus term： 過剰発現 ,  ストレス応答 , 【Automatic Indexing@JST】

Author keywords (5)： amodiaquine ,  quinoneimine ,  cytotoxicity ,  endoplasmic reticulum stress ,  human glutathione S-transferases P1

JST classification (3)： Gene expression  (EC02040Q) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Toxicity of organic compounds  (GZ02030Y)

Substance index (1)： Glutathione

Terms in the title (6)： グルタチオンS-トランスフェラーゼ ,  HepG2細胞 ,  誘導 ,  細胞毒性 ,  小胞体ストレス ,  活性化