Art

J-GLOBAL ID：201802233885195811   Reference number：18A1891359

Genome-wide association study suggests four variants influencing outcomes with ranibizumab therapy in exudative age-related macular degeneration

ゲノムワイド関連研究は滲出性加齢黄斑変性におけるラニビズマブ療法転帰に影響する4つの変異を示唆する

Author (37)： AKIYAMA Masato (RIKEN Center for Integrative Medical Sci., Kanagawa, JPN) ,  AKIYAMA Masato (Kyushu Univ., Fukuoka, JPN) ,  TAKAHASHI Atsushi (RIKEN Center for Integrative Medical Sci., Kanagawa, JPN) ,  TAKAHASHI Atsushi (National Cerebral and Cardiovascular Center, Osaka, JPN) ,  MOMOZAWA Yukihide (RIKEN Center for Integrative Medical Sci., Kanagawa, JPN) ,  ARAKAWA Satoshi (Kyushu Univ., Fukuoka, JPN) ,  ARAKAWA Satoshi (Kyushu Hospital, Fukuoka, JPN) ,  ARAKAWA Satoshi (Steel Memorial Yawata Hospital, Fukuoka, JPN) ,  MIYA Fuyuki (RIKEN Center for Integrative Medical Sci., Kanagawa, JPN) ,  MIYA Fuyuki (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  TSUNODA Tatsuhiko (RIKEN Center for Integrative Medical Sci., Kanagawa, JPN) ,  TSUNODA Tatsuhiko (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  ASHIKAWA Kyota (RIKEN Center for Integrative Medical Sci., Kanagawa, JPN) ,  OSHIMA Yuji (Kyushu Univ., Fukuoka, JPN) ,  OSHIMA Yuji (Fukuoka Univ. Chikushi Hospital, Fukuoka, JPN) ,  YASUDA Miho (Kyushu Univ., Fukuoka, JPN) ,  YOSHIDA Shigeo (Kyushu Univ., Fukuoka, JPN) ,  ENAIDA Hiroshi (Kyushu Univ., Fukuoka, JPN) ,  ENAIDA Hiroshi (Saga Univ. Fac. of Medicine, Saga, JPN) ,  TAN Xue (Univ. Tokyo School of Medicine, Tokyo, JPN) ,  YANAGI Yasuo (Univ. Tokyo School of Medicine, Tokyo, JPN) ,  YANAGI Yasuo (Singapore Eye Res. Inst., Singapore, SGP) ,  YANAGI Yasuo (Singapore National Eye Center, Singapore, SGP) ,  YASUKAWA Tsutomu (Nagoya City Univ. Graduate School of Medical Sci., Aichi, JPN) ,  OGURA Yuichiro (Nagoya City Univ. Graduate School of Medical Sci., Aichi, JPN) ,  NAGAI Yoshimi (Kansai Medical Univ., Osaka, JPN) ,  TAKAHASHI Kanji (Kansai Medical Univ., Osaka, JPN) ,  FUJISAWA Kimihiko (Kyushu Hospital, Fukuoka, JPN) ,  INOUE Maiko (Yokohama City Univ. Medical Center, Kanagawa, JPN) ,  ARAKAWA Akira (Yokohama City Univ. Medical Center, Kanagawa, JPN) ,  ARAKAWA Akira (St. Marianna Univ. School of Medicine, Yokohama, JPN) ,  TANAKA Koji (Nihon Univ. School of Medicine, Tokyo, JPN) ,  YUZAWA Mitsuko (Nihon Univ. School of Medicine, Tokyo, JPN) ,  KADONOSONO Kazuaki (Yokohama City Univ. Graduate School of Medicine, Kanagawa, JPN) ,  SONODA Koh-Hei (Kyushu Univ., Fukuoka, JPN) ,  ISHIBASHI Tatsuro (Kyushu Univ., Fukuoka, JPN) ,  KUBO Michiaki (RIKEN Center for Integrative Medical Sci., Kanagawa, JPN)
Material： Journal of Human Genetics  (J Hum Genet)
Volume： 63  Issue： 10  Page： 1083-1091  Publication year： Oct. 2018 
JST Material Number： Z0756A  ISSN： 1434-5161  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： Genome-Wide Association Study ,...
Semi thesaurus term： VEGF ,...

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JST classification (2)： Drug therapy(=pharmacotherapy)for eye diseases  (GP05020E) ,  Clinical application of drugs acting on sensory organs  (GW04070V)

Reference (30)：

• Lim LS, Mitchell P, Seddon JM, Holz FG, Wong TY. Age-related macular degeneration. Lancet. 2012;379:1728-38.
• Kawasaki R, Yasuda M, Song SJ, Chen SJ, Jonas JB, Wang JJ, et al. The prevalence of age-related macular degeneration in Asians: a systematic review and meta-analysis. Ophthalmology. 2010;117:921-7.
• Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1419-31.
• Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY, et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1432-44.
• Bloch SB, Larsen M, Munch IC. Incidence of legal blindness from age-related macular degeneration in denmark: year 2000 to 2010. Am J Ophthalmol. 2012;153:209-13.

Terms in the title (7)： ゲノム ,  研究 ,  滲出性加齢黄斑変性 ,  ラニビズマブ ,  療法 ,  転帰 ,  変異