Art

J-GLOBAL ID：201802234151347428   Reference number：18A1391183

Design, synthesis and bioevaluation of 2-mercapto-6-phenylpyrimidine-4-carboxylic acid derivatives as potent xanthine oxidase inhibitors

強力なキサンチンオキシダーゼ阻害剤としての2-メルカプト-6-フェニルピリミジン-4-カルボン酸誘導体の設計,合成および生物学的評価【JST・京大機械翻訳】

Author (8)： Shi Ailong (Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China) ,  Zhang Lichao (Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China) ,  Wang He (Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China) ,  Wang Sibo (Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China) ,  Yang Mingzheng (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China) ,  Guan Qi (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China) ,  Bao Kai (Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China) ,  Zhang Weige (Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China)
Material： European Journal of Medicinal Chemistry  (Eur J Med Chem)
Volume： 155  Page： 590-595  Publication year： 2018 
JST Material Number： E0845A  ISSN： 0223-5234  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： A series of 2-mercapto-6-pheny...

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Thesaurus term： enzyme inhibition ,  Structure-Activity Relationship ,  *keto acid ,  enzyme kinetics ,  in vitro experiment ,  molecular modeling ,  50% inhibitory concentration ,  *xanthine oxidase enzyme inhibitor ,  Biological safety evaluation ,  urea compound ,  organosulphur compound
Semi thesaurus term： *阻害剤 ,  定常状態 ,  分子ドッキング ,  生物学的評価 , 【Automatic Indexing@JST】

Author keywords (5)： Xanthine oxidase inhibitors ,  2-Mercapto-6-phenylpyrimidine-4-carboxylic acids ,  Molecular modeling ,  Synthesis ,  Structure-activity relationship

JST classification (1)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (1)： Thiourea

Terms in the title (5)： キサンチンオキシダーゼ阻害剤 ,  カルボン酸 ,  誘導体 ,  設計 ,  生物学的評価