Art

J-GLOBAL ID：201802235399109967   Reference number：18A2052286

Increase in blood-brain barrier permeability does not directly induce neuronal death but may accelerate ischemic neuronal damage

血液脳関門透過性の上昇は神経細胞死を直接的には誘導しないが,虚血性神経細胞死を促進する可能性がある

Author (6)： Ohmori Chiemi (Department of Animal Physiology, Division of Bioscience, Nagahama Institute of Bio-Science and Technology, 1266 Tamura, Nagahama, Shiga 526-0829, Japan) ,  Sakai Yusuke (Department of Animal Physiology, Division of Bioscience, Nagahama Institute of Bio-Science and Technology, 1266 Tamura, Nagahama, Shiga 526-0829, Japan) ,  Matano Yasuki (Department of Animal Physiology, Division of Bioscience, Nagahama Institute of Bio-Science and Technology, 1266 Tamura, Nagahama, Shiga 526-0829, Japan) ,  Suzuki Yasuhiro (School of Pharmaceutical Sciences, Ohu University, 31-1 Tomita-cho Aza Sankaku-do, Koriyama, Fukushima 963-8611, Japan) ,  Umemura Kazuo (Department of Pharmacology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan) ,  Nagai Nobuo (Department of Animal Physiology, Division of Bioscience, Nagahama Institute of Bio-Science and Technology, 1266 Tamura, Nagahama, Shiga 526-0829, Japan)
Material： Experimental Animals  (実験動物ニュース)
Volume： 67  Issue： 4  Page： 479-486(J-STAGE)  Publication year： 2018 
JST Material Number： Z0755A  ISSN： 1341-1357  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： *ischemic brain disorder ,...

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Author keywords (5)： apoptosis ,  blood-brain barrier ,  ischemic stroke ,  neuronal death ,  permeability

JST classification (3)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic neurology  (GN01020W) ,  Central nervous system  (EJ12030F)

Reference (17)：

• 1. Bektas H., Wu T.C., Kasam M., Harun N., Sitton C.W., Grotta J.C., and Savitz S.I. 2010. Increased blood-brain barrier permeability on perfusion CT might predict malignant middle cerebral artery infarction. Stroke 41: 2539-2544.
• 2. Chopp M., Zhang R.L., Chen H., Li Y., Jiang N., and Rusche J.R. 1994. Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats. Stroke 25: 869-875, discussion 875-876.
• 3. Lee S.R., Tsuji K., Lee S.R., and Lo E.H. 2004. Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia. J. Neurosci. 24: 671-678.
• 4. Mhatre M., Nguyen A., Kashani S., Pham T., Adesina A., and Grammas P. 2004. Thrombin, a mediator of neurotoxicity and memory impairment. Neurobiol. Aging 25: 783-793.
• 5. Nagai N., Kawao N., Okada K., Ishida C., Okumoto K., Ueshima S., Suzuki Y., Umemura K., and Matsuo O. 2010. Initial brain lesion size affects the extent of subsequent pathophysiological responses. Brain Res. 1322: 109-117.

Terms in the title (6)： 血液脳関門透過性 ,  神経細胞死 ,  誘導 ,  虚血 ,  促進 ,  可能性