Art

J-GLOBAL ID：201802235682547877   Reference number：18A1377717

Impact of loss-of-function mutations at the RNF43 locus on colorectal cancer development and progression

結腸直腸癌発生と進行に対するRNF43遺伝子座における機能喪失変異の影響【JST・京大機械翻訳】

Author (25)： Eto Tsugio (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Eto Tsugio (International Research Centre for Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Miyake Keisuke (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Miyake Keisuke (International Research Centre for Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Nosho Katsuhiko (Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan) ,  Ohmuraya Masaki (Department of Genetics, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan) ,  Imamura Yu (Department of Gastroenterological Surgery, the Cancer Institute Hospital of JFCR, Tokyo, Japan) ,  Arima Kota (International Research Centre for Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Kanno Shinichi (Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan) ,  Fu Lingfeng (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Fu Lingfeng (International Research Centre for Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Kiyozumi Yuki (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Izumi Daisuke (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Sugihara Hidetaka (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Hiyoshi Yukiharu (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Miyamoto Yuji (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Sawayama Hiroshi (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Iwatsuki Masaaki (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Baba Yoshifumi (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Yoshida Naoya (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Furukawa Toru (Department of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Araki Kimi (Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan) ,  Baba Hideo (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Ishimoto Takatsugu (Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Ishimoto Takatsugu (International Research Centre for Medical Sciences, Kumamoto University, Kumamoto, Japan)
Material： Journal of Pathology  (J Pathol)
Volume： 245  Issue： 4  Page： 445-455  Publication year： 2018 
JST Material Number： B0171A  ISSN： 0022-3417  CODEN： JPTLA  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： RNF43 mutations are frequently...

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Thesaurus term： patient ,  population (statistics) ,  wild type ,  knockout mouse ,  *Mutation ,  hot spot ,  Gene Silencing ,  colorectal neoplasm ,  tumorigenesis ,  Cell Line ,  *Colorectum ,  Japanese ,  *RNF43 ,  Genetic Variation ,  laboratory animal ,  Mus musculus
Semi thesaurus term： variation(biology) ,  *結腸直腸癌 , 【Automatic Indexing@JST】

Author keywords (3)： colorectal cancer ,  RNF43 mutation ,  Wnt signalling

JST classification (2)： Tumors(=neoplasms)of digestive system  (GH04000D) ,  Carcinogenic mechanisms and factors  (GE02020C)

Terms in the title (4)： 結腸直腸癌 ,  RNF43 ,  遺伝子座 ,  機能喪失変異