Art

J-GLOBAL ID：201802235881253987   Reference number：18A1140167

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

CB-1158によるアルギナーゼの阻害は腫瘍微小環境における骨髄細胞媒介免疫抑制を阻止する【JST・京大機械翻訳】

Author (22)： Steggerda Susanne M. (Calithera Biosciences, South San Francisco, USA) ,  Bennett Mark K. (Calithera Biosciences, South San Francisco, USA) ,  Chen Jason (Calithera Biosciences, South San Francisco, USA) ,  Emberley Ethan (Calithera Biosciences, South San Francisco, USA) ,  Huang Tony (Calithera Biosciences, South San Francisco, USA) ,  Janes Julie R. (Calithera Biosciences, South San Francisco, USA) ,  Li Weiqun (Calithera Biosciences, South San Francisco, USA) ,  MacKinnon Andrew L. (Calithera Biosciences, South San Francisco, USA) ,  Makkouk Amani (Calithera Biosciences, South San Francisco, USA) ,  Marguier Gisele (Calithera Biosciences, South San Francisco, USA) ,  Murray Peter J. (Max Planck Institute for Biochemistry, Martinsried, Germany) ,  Murray Peter J. (Departments of Infectious Diseases and Immunology, St. Jude Children’s Research Hospital, Memphis, USA) ,  Neou Silinda (Calithera Biosciences, South San Francisco, USA) ,  Pan Alison (Calithera Biosciences, South San Francisco, USA) ,  Parlati Francesco (Calithera Biosciences, South San Francisco, USA) ,  Rodriguez Mirna L. M. (Calithera Biosciences, South San Francisco, USA) ,  Velde Lee-Ann Van de (Departments of Infectious Diseases and Immunology, St. Jude Children’s Research Hospital, Memphis, USA) ,  Wang Tracy (Calithera Biosciences, South San Francisco, USA) ,  Works Melissa (Calithera Biosciences, South San Francisco, USA) ,  Zhang Jing (Calithera Biosciences, South San Francisco, USA) ,  Zhang Winter (Calithera Biosciences, South San Francisco, USA) ,  Gross Matthew I. (Calithera Biosciences, South San Francisco, USA)
Material： Journal for ImmunoTherapy of Cancer (Web)
Volume： 5  Issue： 1  Page： 101  Publication year： 2017 
JST Material Number： U7507A  ISSN： 2051-1426  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Myeloid cells are an abundant ...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A1140167&from=J-GLOBAL&jstjournalNo=U7507A") }}

Thesaurus term： immunotherapy ,  *tumor ,  gene ,  *myeloid cell ,  protein ,  cell proliferation ,  T cell ,  in vitro experiment ,  inflammation ,  tumor invasion ,  *arginase ,  patient ,  human(primates) ,  drug therapy ,  *immunosuppression

Author keywords (10)： Arg1 ,  Arg2 ,  Arginase ,  Arginine ,  Checkpoint blockade ,  Granulocyte ,  Immunotherapy ,  Myeloid derived suppressor cell ,  Tumor associated macrophage ,  Tumor microenvironment

JST classification (2)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (62)：

• Nat Med; The prognostic landscape of genes and infiltrating immune cells across human cancers; AJ Gentles, AM Newman, CL Liu, SV Bratman, W Feng, D Kim, VS Nair, Y Xu, A Khuong, CD Hoang; 21; 8; 2015; 938-945; 10.1038/nm.3909; citation_id=CR1
• Nat Rev Immunol; Coordinated regulation of myeloid cells by tumours; DI Gabrilovich, S Ostrand-Rosenberg, V Bronte; 12; 4; 2012; 253-268; 10.1038/nri3175; citation_id=CR2
• Bellone M, Elia AR. Constitutive and acquired mechanisms of resistance to immune checkpoint blockade in human cancer. Cytokine Growth Factor Rev. 2017;36:17-24.
• Oncoimmunology; Myeloid derived suppressor cells: targets for therapy; TJ Waldron, JG Quatromoni, TA Karakasheva, S Singhal, AK Rustgi; 2; 4; 2013; 10.4161/onci.24117; citation_id=CR4
• Nat Rev Cancer; The role of myeloid cells in cancer therapies; C Engblom, C Pfirschke, MJ Pittet; 16; 7; 2016; 447-462; 10.1038/nrc.2016.54; citation_id=CR5

Terms in the title (6)： アルギナーゼ ,  阻害 ,  腫瘍微小環境 ,  骨髄細胞 ,  免疫抑制 ,  阻止