Art
J-GLOBAL ID：201802236024533670   Reference number：18A0150683

Synthesis of novel and functionally selective non-competitive muscarinic antagonists as chemical probes

化学プローブとしての新規および機能的に選択的な非競合的ムスカリンきっ抗薬の合成【Powered by NICT】
Author (5)：
Boulos John F.

About Boulos John F.

(Department of Physical Sciences, Barry University, Miami Shores, FL, USA)

About Department of Physical Sciences, Barry University, Miami Shores, FL, USA

, 
Jakubik Jan

About Jakubik Jan

(Department of Neurochemistry, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic)

About Department of Neurochemistry, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic

, 
Boulos John M.

About Boulos John M.

(Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA)

About Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA

, 
Randakova Alena

About Randakova Alena

(Department of Neurochemistry, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic)

About Department of Neurochemistry, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic

, 
Momirov Jelena

About Momirov Jelena

(Department of Physical Sciences, Barry University, Miami Shores, FL, USA)

About Department of Physical Sciences, Barry University, Miami Shores, FL, USA


Material：
Chemical Biology & Drug Design  (Chem Biol Drug Des)

About Chemical Biology & Drug Design


Volume： 91  Issue： 1  Page： 93-104  Publication year： 2018 
JST Material Number： A1436A  ISSN： 1747-0277  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
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Muscarinic receptors are known...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
pilot test

About pilot test

, 
*muscarinic receptor

About muscarinic receptor

, 
interaction

About interaction

, 
receptor

About receptor

, 
pharmacophore

About pharmacophore

, 
*Muscarinic Antagonists

About Muscarinic Antagonists

, 
*chemical probe

About chemical probe

, 
aliphatic amine

About aliphatic amine

, 
aliphatic alcohol

About aliphatic alcohol

, 
carbamate

About carbamate

, 
quaternary ammonium

About quaternary ammonium

, 
aminoalcohol

About aminoalcohol

, 
oxygen heterocyclic compound

About oxygen heterocyclic compound

, 
side chain amine alkaloid

About side chain amine alkaloid


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
サブタイプ

About サブタイプ

, 
*アンタゴニスト

About アンタゴニスト

, 【Automatic Indexing@JST】
Author keywords (5)：
G-protein-coupled receptor

About G-protein-coupled receptor

, 
muscarinic acetylcholine receptor

About muscarinic acetylcholine receptor

, 
N-methylscopolamine

About N-methylscopolamine

, 
Parkinson’s disease

About Parkinson’s disease

, 
positive allosteric modulator

About positive allosteric modulator

JST classification (3)：
JST classification
Category name(code) classified by JST.
Receptors on cell membrane 
(EF04030C)

About Receptors on cell membrane

,  Basic research of psychotropic drugs 
(GW03100Y)

About Basic research of psychotropic drugs

,  Structure-activity relationship of drugs 
(GV01050B)

About Structure-activity relationship of drugs

Substance index (2)：
Substance index
Chemical Substance indexed to the Article.
Carbachol

About Carbachol

, 
Muscarine

About Muscarine

Terms in the title (3)：
Terms in the title
Keywords automatically extracted from the title.
化学プローブ

About 化学プローブ

, 
競合

About 競合

, 
ムスカリンきっ抗薬

About ムスカリンきっ抗薬


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